Extrachromosomal rDNA circles--a cause of aging in yeast. Export

@article{citeulike:2368553, abstract = {Although many cellular and organismal changes have been described in aging individuals, a precise, molecular cause of aging has yet to be found. A prior study of aging yeast mother cells showed a progressive enlargement and fragmentation of the nucleolus. Here we show that these nucleolar changes are likely due to the accumulation of extrachromosomal rDNA circles (ERCs) in old cells and that, in fact, ERCs cause aging. Mutants for sgs1, the yeast homolog of the Werner's syndrome gene, accumulate ERCs more rapidly, leading to premature aging and a shorter life span. We speculate on the generality of this molecular cause of aging in higher species, including mammals.}, address = {Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.}, author = {Sinclair, D. A. and Guarente, L.}, citeulike-article-id = {2368553}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9428525}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9428525}, day = {26}, issn = {0092-8674}, journal = {Cell}, keywords = {erc, yeast}, month = {December}, number = {7}, pages = {1033--1042}, posted-at = {2008-02-13 06:34:48}, priority = {2}, title = {Extrachromosomal rDNA circles--a cause of aging in yeast.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9428525}, volume = {91}, year = {1997} }

TY - JOUR ID - citeulike:2368553 L3 - citeulike-article-id:2368553 N2 - Although many cellular and organismal changes have been described in aging individuals, a precise, molecular cause of aging has yet to be found. A prior study of aging yeast mother cells showed a progressive enlargement and fragmentation of the nucleolus. Here we show that these nucleolar changes are likely due to the accumulation of extrachromosomal rDNA circles (ERCs) in old cells and that, in fact, ERCs cause aging. Mutants for sgs1, the yeast homolog of the Werner's syndrome gene, accumulate ERCs more rapidly, leading to premature aging and a shorter life span. We speculate on the generality of this molecular cause of aging in higher species, including mammals. IS - 7 JF - Cell SN - 0092-8674 AD - Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA. EP - 1042 TI - Extrachromosomal rDNA circles--a cause of aging in yeast. VL - 91 SP - 1033 KW - erc KW - yeast AU - Sinclair, DA AU - Guarente, L PY - 1997/12/26/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9428525 ER -