Biological functions of melanoma-associated antigens. Export

@article{citeulike:2599234, abstract = {To date, dozens of melanoma-associated antigens (MAGEs) have been identified and classified into 2 subgroups, I and II. Subgroup I consists of antigens which expression is generally restricted to tumor or germ cells, also named as cancer/testis (CT) antigen. Proteins and peptides derived from some of these antigens have been utilized in promising clinical trials of immunotherapies for gastrointestinal carcinoma, esophageal carcinoma, pulmonary carcinoma and so on. Various MAGE family members play important physiological and pathological roles during embryogenesis, germ cell genesis, apoptosis, etc. However, little is known regarding the role of MAGE family members in cell activities. It is reasonable to speculate that the genes for subgroup I MAGEs, which play important roles during embryogenesis, could be later deactivated by a genetic mechanism such as methylation. In the case of tumor formation, these genes are reactivated and the resultant proteins may be recognized and attacked by the immune system. Thus, the subgroup I MAGEs may play important roles in the immune surveillance of certain tumor types. Here, we review the classifications of MAGE family genes and what is known of their biological functions.}, address = {Hepatology Institute, People's Hospital, Peking University, Beijing 100044, China.}, author = {Xiao, J. and Chen, H. S.}, citeulike-article-id = {2599234}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15222021}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15222021}, day = {1}, issn = {1007-9327}, journal = {World J Gastroenterol}, keywords = {microarray, ngf, pc12}, month = {July}, number = {13}, pages = {1849--1853}, posted-at = {2008-03-26 17:19:41}, priority = {2}, title = {Biological functions of melanoma-associated antigens.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15222021}, volume = {10}, year = {2004} }

TY - JOUR ID - citeulike:2599234 L3 - citeulike-article-id:2599234 N2 - To date, dozens of melanoma-associated antigens (MAGEs) have been identified and classified into 2 subgroups, I and II. Subgroup I consists of antigens which expression is generally restricted to tumor or germ cells, also named as cancer/testis (CT) antigen. Proteins and peptides derived from some of these antigens have been utilized in promising clinical trials of immunotherapies for gastrointestinal carcinoma, esophageal carcinoma, pulmonary carcinoma and so on. Various MAGE family members play important physiological and pathological roles during embryogenesis, germ cell genesis, apoptosis, etc. However, little is known regarding the role of MAGE family members in cell activities. It is reasonable to speculate that the genes for subgroup I MAGEs, which play important roles during embryogenesis, could be later deactivated by a genetic mechanism such as methylation. In the case of tumor formation, these genes are reactivated and the resultant proteins may be recognized and attacked by the immune system. Thus, the subgroup I MAGEs may play important roles in the immune surveillance of certain tumor types. Here, we review the classifications of MAGE family genes and what is known of their biological functions. IS - 13 JF - World J Gastroenterol SN - 1007-9327 AD - Hepatology Institute, People's Hospital, Peking University, Beijing 100044, China. EP - 1853 TI - Biological functions of melanoma-associated antigens. VL - 10 SP - 1849 KW - microarray KW - ngf KW - pc12 AU - Xiao, J AU - Chen, HS PY - 2004/07/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/15222021 ER -