Identification and characterization of zebrafish semaphorin 6D. Export

@article{citeulike:2599251, abstract = {The semaphorin gene family contains a large number of secreted and transmembrane proteins; some function as repulsive and attractive cues of axon guidance during development. Here, we report cloning and characterization of zebrafish transmembrane semaphorin gene, semaphorin 6D (sema6D). Sema6D is expressed predominantly in the nervous system during embryogenesis, as determined by in situ hybridization. We also found that Sema6D binds Plexin-A1 in vitro, but not other Plexins. It induces the repulsion of dorsal root ganglion axons, but not sympathetic axons. Consequently, Sema6D might use Plexin-A1 as a receptor to repel specific types of axons during development.}, address = {Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.}, author = {Kimura, M. and Taniguchi, M. and Mikami, Y. and Masuda, T. and Yoshida, T. and Mishina, M. and Shimizu, T.}, citeulike-article-id = {2599251}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbrc.2007.09.038}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17897628}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17897628}, day = {23}, doi = {10.1016/j.bbrc.2007.09.038}, issn = {0006-291X}, journal = {Biochem Biophys Res Commun}, keywords = {microarray, ngf, pc12}, month = {November}, number = {3}, pages = {762--768}, posted-at = {2008-03-26 17:26:17}, priority = {2}, title = {Identification and characterization of zebrafish semaphorin 6D.}, url = {http://dx.doi.org/10.1016/j.bbrc.2007.09.038}, volume = {363}, year = {2007} }

TY - JOUR ID - citeulike:2599251 L3 - citeulike-article-id:2599251 N2 - The semaphorin gene family contains a large number of secreted and transmembrane proteins; some function as repulsive and attractive cues of axon guidance during development. Here, we report cloning and characterization of zebrafish transmembrane semaphorin gene, semaphorin 6D (sema6D). Sema6D is expressed predominantly in the nervous system during embryogenesis, as determined by in situ hybridization. We also found that Sema6D binds Plexin-A1 in vitro, but not other Plexins. It induces the repulsion of dorsal root ganglion axons, but not sympathetic axons. Consequently, Sema6D might use Plexin-A1 as a receptor to repel specific types of axons during development. IS - 3 JF - Biochem Biophys Res Commun SN - 0006-291X AD - Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. EP - 768 TI - Identification and characterization of zebrafish semaphorin 6D. VL - 363 SP - 762 KW - microarray KW - ngf KW - pc12 AU - Kimura, M AU - Taniguchi, M AU - Mikami, Y AU - Masuda, T AU - Yoshida, T AU - Mishina, M AU - Shimizu, T PY - 2007/11/23/ UR - http://dx.doi.org/10.1016/j.bbrc.2007.09.038 ER -