The combined effects of morphine and d-amphetamine on the threshold for brain stimulation reward. Export

@article{citeulike:2628230, abstract = {The effect of morphine and d-amphetamine co-administration on the threshold for rewarding intracranial electrical stimulation was studied in rats with electrodes stereotaxically implanted in the medial forebrain bundle-lateral hypothalamic or ventral tegmental area of the brain. Thresholds were determined by means of a rate-independent psychophysical method. Individually, morphine and d-amphetamine both caused a dose-related lowering of the reward threshold. Low doses of morphine or d-amphetamine which were ineffective or minimally effective in lowering the reward threshold were then tested with various doses of either d-amphetamine or morphine, respectively. In both cases, the combined administration of morphine and d-amphetamine resulted in a lowering of the reward threshold that was greater than for the corresponding doses of morphine and d-amphetamine when given alone. Given that increased sensitivity for rewarding brain stimulation has been suggested to be an animal model of drug-induced euphoria, this effect is congruent with the reported increase in the degree of euphoria produced when amphetamine is used in conjunction with opiate drugs.}, address = {Laboratory of Behavioral Pharmacology, Boston University School of Medicine, MA 02118.}, author = {Hubner, C. B. and Bain, G. T. and Kornetsky, C.}, citeulike-article-id = {2628230}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/3685064}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=3685064}, issn = {0091-3057}, journal = {Pharmacology, biochemistry, and behavior}, keywords = {amphetamine, reward}, month = {October}, number = {2}, pages = {311--315}, posted-at = {2008-04-04 02:01:53}, priority = {2}, title = {The combined effects of morphine and d-amphetamine on the threshold for brain stimulation reward.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/3685064}, volume = {28}, year = {1987} }

TY - JOUR ID - citeulike:2628230 L3 - citeulike-article-id:2628230 N2 - The effect of morphine and d-amphetamine co-administration on the threshold for rewarding intracranial electrical stimulation was studied in rats with electrodes stereotaxically implanted in the medial forebrain bundle-lateral hypothalamic or ventral tegmental area of the brain. Thresholds were determined by means of a rate-independent psychophysical method. Individually, morphine and d-amphetamine both caused a dose-related lowering of the reward threshold. Low doses of morphine or d-amphetamine which were ineffective or minimally effective in lowering the reward threshold were then tested with various doses of either d-amphetamine or morphine, respectively. In both cases, the combined administration of morphine and d-amphetamine resulted in a lowering of the reward threshold that was greater than for the corresponding doses of morphine and d-amphetamine when given alone. Given that increased sensitivity for rewarding brain stimulation has been suggested to be an animal model of drug-induced euphoria, this effect is congruent with the reported increase in the degree of euphoria produced when amphetamine is used in conjunction with opiate drugs. IS - 2 JF - Pharmacology, biochemistry, and behavior SN - 0091-3057 AD - Laboratory of Behavioral Pharmacology, Boston University School of Medicine, MA 02118. EP - 315 TI - The combined effects of morphine and d-amphetamine on the threshold for brain stimulation reward. VL - 28 SP - 311 KW - amphetamine KW - reward AU - Hubner, CB AU - Bain, GT AU - Kornetsky, C PY - 1987/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/3685064 ER -