Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds. Export

@article{citeulike:2628239, abstract = {Intracranial self-stimulation was assessed before, within, and after a chronic amphetamine treatment regimen. Amphetamine was given twice daily 5 days per week for 6 weeks at dosages escalating from 1 to 10 mg/kg per injection. Lateral hypothalamic self-stimulation rate-frequency functions were taken 36 h after the last injection in each weekly series and weekly for 3 weeks following the last injection. Frequency thresholds increased and maximal response rates decreased progressively as a function of amphetamine withdrawal during treatment; each returned to near normal levels within 2 weeks of the last injection. When subsequently tested under amphetamine, animals previously receiving the 6-week amphetamine treatment regimen had self-stimulation thresholds and maximal response rates that did not differ significantly from those of saline-treated control animals. These data confirm that chronic amphetamine treatment results in a dependence syndrome characterized in part by a phasic depression in the brain mechanism mediating the reinforcing effects of lateral hypothalamic electrical stimulation.}, address = {Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.}, author = {Wise, R. A. and Munn, E.}, citeulike-article-id = {2628239}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7753958}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7753958}, issn = {0033-3158}, journal = {Psychopharmacology}, keywords = {amphetamine, reward}, month = {January}, number = {2}, pages = {130--136}, posted-at = {2008-04-04 02:15:08}, priority = {2}, title = {Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7753958}, volume = {117}, year = {1995} }

TY - JOUR ID - citeulike:2628239 L3 - citeulike-article-id:2628239 N2 - Intracranial self-stimulation was assessed before, within, and after a chronic amphetamine treatment regimen. Amphetamine was given twice daily 5 days per week for 6 weeks at dosages escalating from 1 to 10 mg/kg per injection. Lateral hypothalamic self-stimulation rate-frequency functions were taken 36 h after the last injection in each weekly series and weekly for 3 weeks following the last injection. Frequency thresholds increased and maximal response rates decreased progressively as a function of amphetamine withdrawal during treatment; each returned to near normal levels within 2 weeks of the last injection. When subsequently tested under amphetamine, animals previously receiving the 6-week amphetamine treatment regimen had self-stimulation thresholds and maximal response rates that did not differ significantly from those of saline-treated control animals. These data confirm that chronic amphetamine treatment results in a dependence syndrome characterized in part by a phasic depression in the brain mechanism mediating the reinforcing effects of lateral hypothalamic electrical stimulation. IS - 2 JF - Psychopharmacology SN - 0033-3158 AD - Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. EP - 136 TI - Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds. VL - 117 SP - 130 KW - amphetamine KW - reward AU - Wise, RA AU - Munn, E PY - 1995/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/7753958 ER -