Does cellular iron dysregulation play a causative role in Parkinson's disease?

@article{citeulike:2832789, abstract = {Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the neuronal cell loss. Here we review evidence for loss of iron homeostasis as a causative factor in disease-associated neurodegeneration and the primary players which may be involved. A series of recent studies suggest that iron regulatory proteins (IRPs) coordinate both cellular iron levels and energy metabolism, both of which are disrupted in Parkinson's disease (PD) and may in turn contribute to increased levels of oxidative stress associated with the disease. Iron has also been recently been implicated in promotion of alpha-synuclein aggregation either directly or via increasing levels of oxidative stress suggesting an important role for it in Lewy body formation, another important hallmark of the disease.}, address = {Buck Institute for Aging Research, 8001 Redwood Blvd, Novato, CA 94945, USA.}, author = {Kaur, D. and Andersen, J. }, citeulike-article-id = {2832789}, doi = {10.1016/j.arr.2004.01.003}, issn = {1568-1637}, journal = {Ageing research reviews}, keywords = {iron, pd}, month = {July}, number = {3}, pages = {327--343}, posted-at = {2008-05-26 05:38:37}, priority = {2}, title = {Does cellular iron dysregulation play a causative role in Parkinson's disease?}, url = {http://dx.doi.org/10.1016/j.arr.2004.01.003}, volume = {3}, year = {2004} }

TY - JOUR ID - citeulike:2832789 L3 - citeulike-article-id:2832789 TI - Does cellular iron dysregulation play a causative role in Parkinson's disease? JF - Ageing research reviews VL - 3 IS - 3 SP - 327 EP - 343 AD - Buck Institute for Aging Research, 8001 Redwood Blvd, Novato, CA 94945, USA. SN - 1568-1637 N2 - Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the neuronal cell loss. Here we review evidence for loss of iron homeostasis as a causative factor in disease-associated neurodegeneration and the primary players which may be involved. A series of recent studies suggest that iron regulatory proteins (IRPs) coordinate both cellular iron levels and energy metabolism, both of which are disrupted in Parkinson's disease (PD) and may in turn contribute to increased levels of oxidative stress associated with the disease. Iron has also been recently been implicated in promotion of alpha-synuclein aggregation either directly or via increasing levels of oxidative stress suggesting an important role for it in Lewy body formation, another important hallmark of the disease. KW - iron KW - pd AU - Kaur, D AU - Andersen, J PY - 2004/07// UR - http://dx.doi.org/10.1016/j.arr.2004.01.003 ER -