Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. Export

@article{citeulike:3514871, abstract = {The neural cell adhesion molecule (NCAM) is a cell surface glycoprotein which is thought to mediate cell adhesion and recognition. During developmental stages, NCAM is highly polysialylated (NCAM-H) by a unique alpha-2,8-linked polysialic acid chain (PSA), and this PSA portion of NCAM-H has been found to be closely associated with various developmental processes of the nervous system. Further, recent immunohistochemical investigations have revealed that even in the adult nervous system, a persistent PSA expression has been found confined to several regions: the olfactory bulb, the piriform cortex, the hippocampal dentate gyrus, the hypothalamus, some nuclei of the medulla and the dorsal horn of the spinal cord, which are related directly or indirectly to sensory systems. Moreover, in the dentate gyrus and olfactory bulb the expression is connected with adult neurogenesis that may add new neuronal circuits to the adult neural tissue. Therefore, the possible role of NCAM-H in the central nervous system may be associated not only with neural development, but also with adult functions, such as the processing system of sensory information and neuronal plasticity.}, author = {Seki, T. and Arai, Y.}, citeulike-article-id = {3514871}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8264989}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8264989}, issn = {0168-0102}, journal = {Neuroscience research}, keywords = {npc, psancam}, month = {September}, number = {4}, pages = {265--290}, posted-at = {2008-11-14 18:32:19}, priority = {2}, title = {Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8264989}, volume = {17}, year = {1993} }

TY - JOUR ID - citeulike:3514871 L3 - citeulike-article-id:3514871 N2 - The neural cell adhesion molecule (NCAM) is a cell surface glycoprotein which is thought to mediate cell adhesion and recognition. During developmental stages, NCAM is highly polysialylated (NCAM-H) by a unique alpha-2,8-linked polysialic acid chain (PSA), and this PSA portion of NCAM-H has been found to be closely associated with various developmental processes of the nervous system. Further, recent immunohistochemical investigations have revealed that even in the adult nervous system, a persistent PSA expression has been found confined to several regions: the olfactory bulb, the piriform cortex, the hippocampal dentate gyrus, the hypothalamus, some nuclei of the medulla and the dorsal horn of the spinal cord, which are related directly or indirectly to sensory systems. Moreover, in the dentate gyrus and olfactory bulb the expression is connected with adult neurogenesis that may add new neuronal circuits to the adult neural tissue. Therefore, the possible role of NCAM-H in the central nervous system may be associated not only with neural development, but also with adult functions, such as the processing system of sensory information and neuronal plasticity. IS - 4 JF - Neuroscience research SN - 0168-0102 EP - 290 TI - Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. VL - 17 SP - 265 KW - npc KW - psancam AU - Seki, T AU - Arai, Y PY - 1993/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/8264989 ER -