Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Export

@article{citeulike:4280592, abstract = {alpha-Synuclein (alpha-Syn) is a 14 kDa protein of unknown function that has been implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that alpha-Syn-/- mice are viable and fertile, exhibit intact brain architecture, and possess a normal complement of dopaminergic cell bodies, fibers, and synapses. Nigrostriatal terminals of alpha-Syn-/- mice display a standard pattern of dopamine (DA) discharge and reuptake in response to simple electrical stimulation. However, they exhibit an increased release with paired stimuli that can be mimicked by elevated Ca2+. Concurrent with the altered DA release, alpha-Syn-/- mice display a reduction in striatal DA and an attenuation of DA-dependent locomotor response to amphetamine. These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission.}, author = {Abeliovich, A. and Schmitz, Y. and Fari\~{n}as, I. and Choi-Lundberg, D. and Ho, W. H. and Castillo, P. E. and Shinsky, N. and Verdugo, J. M. and Armanini, M. and Ryan, A. and Hynes, M. and Phillips, H. and Sulzer, D. and Rosenthal, A.}, citeulike-article-id = {4280592}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10707987}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10707987}, issn = {0896-6273}, journal = {Neuron}, keywords = {pd, syn}, month = {January}, number = {1}, pages = {239--252}, posted-at = {2009-04-06 23:05:48}, priority = {2}, title = {Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10707987}, volume = {25}, year = {2000} }

TY - JOUR ID - citeulike:4280592 L3 - citeulike-article-id:4280592 N2 - alpha-Synuclein (alpha-Syn) is a 14 kDa protein of unknown function that has been implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that alpha-Syn-/- mice are viable and fertile, exhibit intact brain architecture, and possess a normal complement of dopaminergic cell bodies, fibers, and synapses. Nigrostriatal terminals of alpha-Syn-/- mice display a standard pattern of dopamine (DA) discharge and reuptake in response to simple electrical stimulation. However, they exhibit an increased release with paired stimuli that can be mimicked by elevated Ca2+. Concurrent with the altered DA release, alpha-Syn-/- mice display a reduction in striatal DA and an attenuation of DA-dependent locomotor response to amphetamine. These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission. IS - 1 JF - Neuron SN - 0896-6273 EP - 252 TI - Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. VL - 25 SP - 239 KW - pd KW - syn AU - Abeliovich, A AU - Schmitz, Y AU - Fariñas, I AU - Choi-Lundberg, D AU - Ho, WH AU - Castillo, PE AU - Shinsky, N AU - Verdugo, JM AU - Armanini, M AU - Ryan, A AU - Hynes, M AU - Phillips, H AU - Sulzer, D AU - Rosenthal, A PY - 2000/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/10707987 ER -