Biodegradable poly(ether-ester) multiblock copolymers for controlled release applications: An <I>in vivo</I> evaluation Export

@article{citeulike:5944390, abstract = {Multiblock poly(ether-ester)s based on poly(ethylene glycol), butylene terephthalate, and butylene succinate segments were evaluated for their in vivo degradation and biocompatibility in order to establish a correlation with previously reported in vitro results. Porous polymer sheets were implanted subcutaneously for 32 weeks in rats. The degradation was monitored visually (histology), by molecular weight (GPC), and by copolymer composition (NMR). Substitution of the aromatic terephthalate units by aliphatic succinate units was shown to accelerate the degradation rate of the copolymers. Direct correlation of the in vivo and in vitro degradation of the porous implants showed a slightly faster initial molecular weight decrease in vivo. Besides hydrolysis, oxidation occurs in vivo due to the presence of radicals produced by inflammatory cells. In addition, the higher molecular weight plateau of the residue found in vivo indicated a higher solubility of the oligomers in the extracellular fluid compared to a phosphate buffer. Minor changes in the poly(ether-ester) compositions were noted due to degradation. Microscopically, fragmentation of the porous implants was observed in time. At later stages of degradation, macrophages were observed phagocytozing small polymer particles. Both in vitro cytotoxicity studies and histology on in vivo samples proved the biocompatibility of the poly(ether-ester)s. {\copyright} 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 118-127, 2004}, address = {OctoPlus Technologies B.V., Zernikedreef 12, 2333 CL, Leiden, The Netherlands; IsoTis OrthoBiologics, Prof. Bronkhorstlaan 10-D, 3723 MB Bilthoven, The Netherlands; Institute for Biomedical Technology (BMTI), Faculty of Chemical Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands}, author = {van Dijkhuizen-Radersma, R. and Roosma, J. R. and Sohier, J. and P\'{e}ters and van den Doel, M. and van Blitterswijk, C. A. and de Groot, K. and Bezemer, J. M.}, citeulike-article-id = {5944390}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jbm.a.30136}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/109585318/ABSTRACT}, doi = {10.1002/jbm.a.30136}, issn = {1552-4965}, journal = {Journal of Biomedical Materials Research Part A}, keywords = {biocompatibility, cytotoxicity, erosion, ivivc, polyether-ester}, number = {1}, pages = {118--127}, posted-at = {2009-10-15 15:54:58}, priority = {2}, title = {Biodegradable poly(ether-ester) multiblock copolymers for controlled release applications: An <I>in vivo</I> evaluation}, url = {http://dx.doi.org/10.1002/jbm.a.30136}, volume = {71A}, year = {2004} }

TY - JOUR ID - citeulike:5944390 L3 - citeulike-article-id:5944390 N2 - Multiblock poly(ether-ester)s based on poly(ethylene glycol), butylene terephthalate, and butylene succinate segments were evaluated for their in vivo degradation and biocompatibility in order to establish a correlation with previously reported in vitro results. Porous polymer sheets were implanted subcutaneously for 32 weeks in rats. The degradation was monitored visually (histology), by molecular weight (GPC), and by copolymer composition (NMR). Substitution of the aromatic terephthalate units by aliphatic succinate units was shown to accelerate the degradation rate of the copolymers. Direct correlation of the in vivo and in vitro degradation of the porous implants showed a slightly faster initial molecular weight decrease in vivo. Besides hydrolysis, oxidation occurs in vivo due to the presence of radicals produced by inflammatory cells. In addition, the higher molecular weight plateau of the residue found in vivo indicated a higher solubility of the oligomers in the extracellular fluid compared to a phosphate buffer. Minor changes in the poly(ether-ester) compositions were noted due to degradation. Microscopically, fragmentation of the porous implants was observed in time. At later stages of degradation, macrophages were observed phagocytozing small polymer particles. Both in vitro cytotoxicity studies and histology on in vivo samples proved the biocompatibility of the poly(ether-ester)s. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 118-127, 2004 IS - 1 JF - Journal of Biomedical Materials Research Part A SN - 1552-4965 AD - OctoPlus Technologies B.V., Zernikedreef 12, 2333 CL, Leiden, The Netherlands; IsoTis OrthoBiologics, Prof. Bronkhorstlaan 10-D, 3723 MB Bilthoven, The Netherlands; Institute for Biomedical Technology (BMTI), Faculty of Chemical Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands EP - 127 TI - Biodegradable poly(ether-ester) multiblock copolymers for controlled release applications: An <I>in vivo</I> evaluation VL - 71A SP - 118 KW - biocompatibility KW - cytotoxicity KW - erosion KW - ivivc KW - polyether-ester AU - van Dijkhuizen-Radersma, R AU - Roosma, JR AU - Sohier, J AU - Péters AU - van den Doel, M AU - van Blitterswijk, CA AU - de Groot, K AU - Bezemer, JM PY - 2004/// UR - http://dx.doi.org/10.1002/jbm.a.30136 ER -