Poly(ether ester amide)s for tissue engineering Export

@article{citeulike:5980446, abstract = {Poly(ether ester amide) (PEEA) copolymers based on poly(ethylene glycol) (PEG), 1,4-butanediol and dimethyl-7,12-diaza-6,13-dione-1,18-octadecanedioate were evaluated as scaffold materials for tissue engineering. A PEEA copolymer based on PEG with a molecular weight of 300 g/mol and 25 wt\% of soft segments (300 PEEA 25/75) and the parent PEA polymer (0/100) sustain the adhesion and growth of endothelial cells. The in vivo degradation of melt-pressed PEEA and PEA discs subcutaneously implanted in the back of male Wistar rats was followed up to 14 weeks. Depending on the copolymer composition, a decrease in intrinsic viscosity of about 20–30\% and mass loss up to 12\% were measured. During the degradation process, erosion of the surface was observed by scanning electron microscopy and light microscopy. The thermal properties of the polymers during degradation were measured by differential scanning calorimetry. During the first 2 weeks, a broadening of the melting endotherm was observed, as well as an increase in the heat of fusion. Porous matrices of PEEAs and PEA could be prepared by molding mixtures of polymer and salt particles followed by leaching of the salt.}, author = {Deschamps, A. and van Apeldoorn, A. A. and de Bruijn, J. D. and Grijpma, D. W. and Feijen, J.}, citeulike-article-id = {5980446}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0142-9612(03)00054-1}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0142-9612(03)00054-1}, doi = {10.1016/S0142-9612(03)00054-1}, issn = {01429612}, journal = {Biomaterials}, keywords = {biodegradation, erosion, polyether-ester\_amides, tissue\_engineering}, month = {July}, number = {15}, pages = {2643--2652}, posted-at = {2009-10-21 14:10:58}, priority = {2}, title = {Poly(ether ester amide)s for tissue engineering}, url = {http://dx.doi.org/10.1016/S0142-9612(03)00054-1}, volume = {24}, year = {2003} }

TY - JOUR ID - citeulike:5980446 L3 - citeulike-article-id:5980446 N2 - Poly(ether ester amide) (PEEA) copolymers based on poly(ethylene glycol) (PEG), 1,4-butanediol and dimethyl-7,12-diaza-6,13-dione-1,18-octadecanedioate were evaluated as scaffold materials for tissue engineering. A PEEA copolymer based on PEG with a molecular weight of 300 g/mol and 25 wt% of soft segments (300 PEEA 25/75) and the parent PEA polymer (0/100) sustain the adhesion and growth of endothelial cells. The in vivo degradation of melt-pressed PEEA and PEA discs subcutaneously implanted in the back of male Wistar rats was followed up to 14 weeks. Depending on the copolymer composition, a decrease in intrinsic viscosity of about 20–30% and mass loss up to 12% were measured. During the degradation process, erosion of the surface was observed by scanning electron microscopy and light microscopy. The thermal properties of the polymers during degradation were measured by differential scanning calorimetry. During the first 2 weeks, a broadening of the melting endotherm was observed, as well as an increase in the heat of fusion. Porous matrices of PEEAs and PEA could be prepared by molding mixtures of polymer and salt particles followed by leaching of the salt. IS - 15 JF - Biomaterials SN - 01429612 EP - 2652 TI - Poly(ether ester amide)s for tissue engineering VL - 24 SP - 2643 KW - biodegradation KW - erosion KW - polyether-ester_amides KW - tissue_engineering AU - Deschamps, A AU - van Apeldoorn, AA AU - de Bruijn, JD AU - Grijpma, DW AU - Feijen, J PY - 2003/07// UR - http://dx.doi.org/10.1016/S0142-9612(03)00054-1 ER -