Sugar-Sweetened Beverages and Genetic Risk of Obesity

Obesity has become a major threat to public health throughout the world.1 The dramatic changes in diet and lifestyle during the past three decades are believed to have played a key role in triggering the obesity epidemic.2 In the past several years, large-scale genomewide association studies have successfully identified multiple loci associated with the body-mass index (BMI); these loci consist of commonly distributed variants that determine the overall susceptibility to obesity.3 A meta-analysis of genomewide association studies has established that 32 loci are associated with BMI at a genomewide significance level.4,5 However, few studies have examined the interaction between . . .