Gastrointestinal symptoms in patients with liver cirrhosis: Associations with nutritional status and health-related quality of life Export

@article{citeulike:3564421, abstract = {<i><b>Objective.</b></i> Gastrointestinal symptoms can lead to decreased food intake and thereby increased morbidity. There is a general lack of data on the prevalence of gastrointestinal symptoms and their potential association with malnutrition and health-related quality of life (QoL) in cirrhosis. Our aim was to prospectively evaluate gastrointestinal symptoms, malnutrition, and QoL in patients with cirrhosis. <i><b>Material and methods.</b></i> Two validated questionnaires were used to measure gastrointestinal symptoms (gastrointestinal symptom rating scale (GSRS)) and health-related QoL (SF-36) in 128 consecutive cirrhotics (mean age 57 years, Child-Pugh score 8.6, MELD score 13.2) at a tertiary referral center. The results were compared with those of controls from the general population. Nutritional status was assessed by anthropometry and estimation of recent weight change. <i><b>Results.</b></i> Compared to controls, cirrhotic patients showed higher gastrointestinal symptom severity (total GSRS score: 1.53, 95\% CI 1.50–1.55 versus 2.21, 95\% CI 2.04–2.38) and profound reductions in the SF-36 physical (47.0 95\% CI 45.0–49.0 versus 37.9, 95\% CI 35.7–40.1) and mental component summary scores (51.0 95\% CI 49.0–53.0 versus 39.2 95\% CI 36.7–41.6). There were no significant differences in any GSRS domain between patients with and those without malnutrition. Multivariate analysis showed that gastrointestinal symptom severity was associated with the Child-Pugh score (beta\&hairsp;=\&hairsp;0.10, <i>r</i>\&lt;0.05), daily lactulose use (beta\&hairsp;=\&hairsp;0.65, <i>p</i>\&lt;0.005), and the presence of gastrointestinal comorbidities (beta\&hairsp;=\&hairsp;0.51, <i>p</i>\&lt;0.05). Negative weight change (beta\&hairsp;=\&hairsp;-\&hairsp;0.72, <i>p</i>\&lt;0.05) and the SF-36 physical (beta\&hairsp;=\&hairsp;-\&hairsp;4.26, <i>p</i>\&lt;0.005) and mental (beta\&hairsp;=\&hairsp;-\&hairsp;4.53, <i>p</i>\&lt;0.005) summaries were independently related to gastrointestinal symptom severity. <i><b>Conclusions.</b></i> Patients with cirrhosis show increased severity of gastrointestinal symptoms, which are associated with recent weight loss and impaired health-related QoL. The severity of gastrointestinal symptoms seems to be related to the severity of cirrhosis.}, author = {Kalaitzakis, Evangelos and Simr\'{e}n, Magnus and Olsson, Rolf and Henfridsson, Pia and Hugosson, Irene and Bengtsson, Maria and Bj\"{o}rnsson, Einar}, citeulike-article-id = {3564421}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/00365520600825117}, doi = {10.1080/00365520600825117}, journal = {Scandinavian Journal of Gastroenterology}, number = {12}, pages = {1464--1472}, posted-at = {2008-11-18 09:08:42}, priority = {2}, publisher = {Informa Healthcare}, title = {Gastrointestinal symptoms in patients with liver cirrhosis: Associations with nutritional status and health-related quality of life}, url = {http://dx.doi.org/10.1080/00365520600825117}, volume = {41}, year = {2006} }

TY - JOUR ID - citeulike:3564421 L3 - citeulike-article-id:3564421 N2 - <i><b>Objective.</b></i> Gastrointestinal symptoms can lead to decreased food intake and thereby increased morbidity. There is a general lack of data on the prevalence of gastrointestinal symptoms and their potential association with malnutrition and health-related quality of life (QoL) in cirrhosis. Our aim was to prospectively evaluate gastrointestinal symptoms, malnutrition, and QoL in patients with cirrhosis. <i><b>Material and methods.</b></i> Two validated questionnaires were used to measure gastrointestinal symptoms (gastrointestinal symptom rating scale (GSRS)) and health-related QoL (SF-36) in 128 consecutive cirrhotics (mean age 57 years, Child-Pugh score 8.6, MELD score 13.2) at a tertiary referral center. The results were compared with those of controls from the general population. Nutritional status was assessed by anthropometry and estimation of recent weight change. <i><b>Results.</b></i> Compared to controls, cirrhotic patients showed higher gastrointestinal symptom severity (total GSRS score: 1.53, 95% CI 1.50–1.55 versus 2.21, 95% CI 2.04–2.38) and profound reductions in the SF-36 physical (47.0 95% CI 45.0–49.0 versus 37.9, 95% CI 35.7–40.1) and mental component summary scores (51.0 95% CI 49.0–53.0 versus 39.2 95% CI 36.7–41.6). There were no significant differences in any GSRS domain between patients with and those without malnutrition. Multivariate analysis showed that gastrointestinal symptom severity was associated with the Child-Pugh score (beta&hairsp;=&hairsp;0.10, <i>r</i>&lt;0.05), daily lactulose use (beta&hairsp;=&hairsp;0.65, <i>p</i>&lt;0.005), and the presence of gastrointestinal comorbidities (beta&hairsp;=&hairsp;0.51, <i>p</i>&lt;0.05). Negative weight change (beta&hairsp;=&hairsp;-&hairsp;0.72, <i>p</i>&lt;0.05) and the SF-36 physical (beta&hairsp;=&hairsp;-&hairsp;4.26, <i>p</i>&lt;0.005) and mental (beta&hairsp;=&hairsp;-&hairsp;4.53, <i>p</i>&lt;0.005) summaries were independently related to gastrointestinal symptom severity. <i><b>Conclusions.</b></i> Patients with cirrhosis show increased severity of gastrointestinal symptoms, which are associated with recent weight loss and impaired health-related QoL. The severity of gastrointestinal symptoms seems to be related to the severity of cirrhosis. IS - 12 JF - Scandinavian Journal of Gastroenterology EP - 1472 TI - Gastrointestinal symptoms in patients with liver cirrhosis: Associations with nutritional status and health-related quality of life PB - Informa Healthcare VL - 41 SP - 1464 AU - Kalaitzakis, Evangelos AU - Simrén, Magnus AU - Olsson, Rolf AU - Henfridsson, Pia AU - Hugosson, Irene AU - Bengtsson, Maria AU - Björnsson, Einar PY - 2006/// UR - http://dx.doi.org/10.1080/00365520600825117 ER -