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Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis

by: Melih Tutuncu, Junger Tang, Nuhad A. Zeid, Nilufer Kale, Daniel J. Crusan, Elizabeth J. Atkinson, Aksel Siva, Sean J. Pittock, Istvan Pirko, B. Mark Keegan, Claudia F. Lucchinetti, John H. Noseworthy, Moses Rodriguez, Brian G. Weinshenker, Orhun H. Kantarci
Multiple Sclerosis Journal (26 June 2012), doi:10.1177/1352458512451510  Key: citeulike:10844570

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Abstract

Background: It is unclear if all patients with relapsing–remitting multiple sclerosis (RRMS) ultimately develop progressive MS. Onset of progressive disease course seems to be age- rather than disease duration-dependent. Some forms of progressive MS (e.g. primary progressive MS (PPMS)) are uncommon in population-based studies. Ascertainment of patients with PPMS from clinic-based populations can facilitate a powerful comparison of age at progression onset between secondary progressive MS (SPMS) and PPMS but may introduce unclear biases.


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