Reduced accumulation of specific microRNAs in colorectal neoplasia. Export

@article{citeulike:550509, abstract = {Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin formation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, consistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia.}, address = {Department of Gastroenterology and Hepatology, Flinders Centre for Digestive Health, Flinders Medical Centre, South Australia, Australia. michael.michael@flinders.edu.au}, author = {Michael, M. Z. and O' Connor, S. M. and van Holst Pellekaan, N. G. and Young, G. P. and James, R. J.}, citeulike-article-id = {550509}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/14573789}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=14573789}, issn = {1541-7786}, journal = {Mol Cancer Res}, keywords = {colorectal\_neoplasia, disorder, microrna}, month = {October}, number = {12}, pages = {882--891}, posted-at = {2006-03-14 10:44:47}, priority = {2}, title = {Reduced accumulation of specific microRNAs in colorectal neoplasia.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14573789}, volume = {1}, year = {2003} }

TY - JOUR ID - citeulike:550509 L3 - citeulike-article-id:550509 N2 - Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin formation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, consistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia. IS - 12 JF - Mol Cancer Res SN - 1541-7786 AD - Department of Gastroenterology and Hepatology, Flinders Centre for Digestive Health, Flinders Medical Centre, South Australia, Australia. michael.michael@flinders.edu.au EP - 891 TI - Reduced accumulation of specific microRNAs in colorectal neoplasia. VL - 1 SP - 882 KW - colorectal_neoplasia KW - disorder KW - microrna AU - Michael, MZ AU - O' Connor, SM AU - van Holst Pellekaan, NG AU - Young, GP AU - James, RJ PY - 2003/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/14573789 ER -