Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif. Export

@article{citeulike:552160, abstract = {Fragile X mental retardation protein (FMRP), the protein responsible for the fragile X syndrome, is an RNA-binding protein involved in localization and translation of neuronal mRNAs. One of the RNAs known to interact with FMRP is the dendritic non-translatable brain cytoplasmic RNA 1 BC1 RNA that works as an adaptor molecule linking FMRP and some of its regulated mRNAs. Here, we showed that the N terminus of FMRP binds strongly and specifically to BC1 and to its potential human analog BC200. This region does not contain a motif known to specifically recognize RNA and thus constitutes a new RNA-binding motif. We further demonstrated that FMRP recognition involves the 5' stem loop of BC1 and that this is the region that exhibits complementarity to FMRP target mRNAs, raising the possibility that FMRP plays a direct role in BC1/mRNA annealing.}, address = {Dipartimento di Biologia, Universit\`{a} Tor Vergata, 00133 Rome, Italy.}, author = {Zalfa, F. and Adinolfi, S. and Napoli, I. and K\"{u}hn-H\"{o}lsken, E. and Urlaub, H. and Achsel, T. and Pastore, A. and Bagni, C.}, citeulike-article-id = {552160}, citeulike-linkout-0 = {http://dx.doi.org/10.1074/jbc.M504286200}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16006558}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16006558}, day = {30}, doi = {10.1074/jbc.M504286200}, issn = {0021-9258}, journal = {J Biol Chem}, keywords = {bc1, bc200, disorder, fmrp, ncrna, neural}, month = {September}, number = {39}, pages = {33403--33410}, posted-at = {2006-03-15 02:39:07}, priority = {2}, title = {Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.}, url = {http://dx.doi.org/10.1074/jbc.M504286200}, volume = {280}, year = {2005} }

TY - JOUR ID - citeulike:552160 L3 - citeulike-article-id:552160 N2 - Fragile X mental retardation protein (FMRP), the protein responsible for the fragile X syndrome, is an RNA-binding protein involved in localization and translation of neuronal mRNAs. One of the RNAs known to interact with FMRP is the dendritic non-translatable brain cytoplasmic RNA 1 BC1 RNA that works as an adaptor molecule linking FMRP and some of its regulated mRNAs. Here, we showed that the N terminus of FMRP binds strongly and specifically to BC1 and to its potential human analog BC200. This region does not contain a motif known to specifically recognize RNA and thus constitutes a new RNA-binding motif. We further demonstrated that FMRP recognition involves the 5' stem loop of BC1 and that this is the region that exhibits complementarity to FMRP target mRNAs, raising the possibility that FMRP plays a direct role in BC1/mRNA annealing. IS - 39 JF - J Biol Chem SN - 0021-9258 AD - Dipartimento di Biologia, Università Tor Vergata, 00133 Rome, Italy. EP - 33410 TI - Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif. VL - 280 SP - 33403 KW - bc1 KW - bc200 KW - disorder KW - fmrp KW - ncrna KW - neural AU - Zalfa, F AU - Adinolfi, S AU - Napoli, I AU - Kühn-Hölsken, E AU - Urlaub, H AU - Achsel, T AU - Pastore, A AU - Bagni, C PY - 2005/09/30/ UR - http://dx.doi.org/10.1074/jbc.M504286200 ER -