Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Export

@article{citeulike:756504, abstract = {Expression profiling of T24 cells revealed that 17 out of 313 human miRNAs were upregulated more than 3-fold by simultaneous treatment with the chromatin-modifying drugs 5-aza-2'-deoxycytidine and 4-phenylbutyric acid. One of these, miR-127, is embedded in a CpG island and is highly induced from its own promoter after treatment. miR-127 is usually expressed as part of a miRNA cluster in normal cells but not in cancer cells, suggesting that it is subject to epigenetic silencing. In addition, the proto-oncogene BCL6, a potential target of miR-127, was translationally downregulated after treatment. These results suggest that DNA demethylation and histone deacetylase inhibition can activate expression of miRNAs that may act as tumor suppressors.}, address = {Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.}, author = {Saito, Y. and Liang, G. and Egger, G. and Friedman, J. M. and Chuang, J. C. and Coetzee, G. A. and Jones, P. A.}, citeulike-article-id = {756504}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ccr.2006.04.020}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16766263}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16766263}, doi = {10.1016/j.ccr.2006.04.020}, issn = {1535-6108}, journal = {Cancer Cell}, keywords = {function, microrna, ncrna}, month = {June}, number = {6}, pages = {435--443}, posted-at = {2006-07-13 07:55:28}, priority = {2}, title = {Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.}, url = {http://dx.doi.org/10.1016/j.ccr.2006.04.020}, volume = {9}, year = {2006} }

TY - JOUR ID - citeulike:756504 L3 - citeulike-article-id:756504 N2 - Expression profiling of T24 cells revealed that 17 out of 313 human miRNAs were upregulated more than 3-fold by simultaneous treatment with the chromatin-modifying drugs 5-aza-2'-deoxycytidine and 4-phenylbutyric acid. One of these, miR-127, is embedded in a CpG island and is highly induced from its own promoter after treatment. miR-127 is usually expressed as part of a miRNA cluster in normal cells but not in cancer cells, suggesting that it is subject to epigenetic silencing. In addition, the proto-oncogene BCL6, a potential target of miR-127, was translationally downregulated after treatment. These results suggest that DNA demethylation and histone deacetylase inhibition can activate expression of miRNAs that may act as tumor suppressors. IS - 6 JF - Cancer Cell SN - 1535-6108 AD - Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA. EP - 443 TI - Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. VL - 9 SP - 435 KW - function KW - microrna KW - ncrna AU - Saito, Y AU - Liang, G AU - Egger, G AU - Friedman, JM AU - Chuang, JC AU - Coetzee, GA AU - Jones, PA PY - 2006/06// UR - http://dx.doi.org/10.1016/j.ccr.2006.04.020 ER -