Diversity of microRNAs in human and chimpanzee brain Export

@article{citeulike:921343, abstract = {We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.}, address = {Hubrecht Laboratory–KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.}, author = {Berezikov, Eugene and Thuemmler, Fritz and van Laake, Linda W. and Kondova, Ivanela and Bontrop, Ronald and Cuppen, Edwin and Plasterk, Ronald H. A.}, citeulike-article-id = {921343}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng1914}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng1914}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17072315}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17072315}, day = {29}, doi = {10.1038/ng1914}, issn = {1061-4036}, journal = {Nature Genetics}, keywords = {brain, evolution, microrna, ncrna}, month = {October}, number = {12}, pages = {1375--1377}, posted-at = {2006-11-01 08:27:44}, priority = {0}, publisher = {Nature Publishing Group}, title = {Diversity of microRNAs in human and chimpanzee brain}, url = {http://dx.doi.org/10.1038/ng1914}, volume = {38}, year = {2006} }

TY - JOUR ID - citeulike:921343 L3 - citeulike-article-id:921343 N2 - We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs. IS - 12 JF - Nature Genetics SN - 1061-4036 AD - Hubrecht Laboratory–KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. EP - 1377 TI - Diversity of microRNAs in human and chimpanzee brain PB - Nature Publishing Group VL - 38 SP - 1375 KW - brain KW - evolution KW - microrna KW - ncrna AU - Berezikov, Eugene AU - Thuemmler, Fritz AU - van Laake, Linda AU - Kondova, Ivanela AU - Bontrop, Ronald AU - Cuppen, Edwin AU - Plasterk, Ronald PY - 2006/10/29/ UR - http://dx.doi.org/10.1038/ng1914 ER -