Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Export

@article{citeulike:4936709, abstract = {Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.}, author = {Maji, Samir K. and Perrin, Marilyn H. and Sawaya, Michael R. and Jessberger, Sebastian and Vadodaria, Krishna and Rissman, Robert A. and Singru, Praful S. and Nilsson, K. Peter and Simon, Rozalyn and Schubert, David and Eisenberg, David and Rivier, Jean and Sawchenko, Paul and Vale, Wylie and Riek, Roland}, citeulike-article-id = {4936709}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1173155}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5938/328}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19541956}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19541956}, day = {17}, doi = {10.1126/science.1173155}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {amyloids, hormones, journalclub, prions}, month = {July}, number = {5938}, pages = {328--332}, posted-at = {2009-07-21 01:46:00}, priority = {2}, title = {Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.}, url = {http://dx.doi.org/10.1126/science.1173155}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:4936709 L3 - citeulike-article-id:4936709 N2 - Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology. IS - 5938 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 332 TI - Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. VL - 325 SP - 328 KW - amyloids KW - hormones KW - journalclub KW - prions AU - Maji, Samir AU - Perrin, Marilyn AU - Sawaya, Michael AU - Jessberger, Sebastian AU - Vadodaria, Krishna AU - Rissman, Robert AU - Singru, Praful AU - Nilsson, Peter AU - Simon, Rozalyn AU - Schubert, David AU - Eisenberg, David AU - Rivier, Jean AU - Sawchenko, Paul AU - Vale, Wylie AU - Riek, Roland PY - 2009/07/17/ UR - http://dx.doi.org/10.1126/science.1173155 ER -