Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila Export

@article{citeulike:4265784, abstract = {Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, although recent work suggests that sleep, memory, and plasticity are linked. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in Drosophila, we found that protein levels of key components of central synapses were high after waking and low after sleep. These changes were related to behavioral state rather than time of day and occurred in all major areas of the Drosophila brain. The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities. 10.1126/science.1166673}, author = {Gilestro, Giorgio F. and Tononi, Giulio and Cirelli, Chiara}, citeulike-article-id = {4265784}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1166673}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5923/109}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19342593}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19342593}, day = {3}, doi = {10.1126/science.1166673}, journal = {Science}, keywords = {drosophila, memory, sleep}, month = {April}, number = {5923}, pages = {109--112}, posted-at = {2009-04-03 13:26:28}, priority = {2}, title = {Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila}, url = {http://dx.doi.org/10.1126/science.1166673}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4265784 L3 - citeulike-article-id:4265784 N2 - Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, although recent work suggests that sleep, memory, and plasticity are linked. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in Drosophila, we found that protein levels of key components of central synapses were high after waking and low after sleep. These changes were related to behavioral state rather than time of day and occurred in all major areas of the Drosophila brain. The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities. 10.1126/science.1166673 IS - 5923 JF - Science EP - 112 TI - Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila VL - 324 SP - 109 KW - drosophila KW - memory KW - sleep AU - Gilestro, Giorgio AU - Tononi, Giulio AU - Cirelli, Chiara PY - 2009/04/03/ UR - http://dx.doi.org/10.1126/science.1166673 ER -