ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues? Export

@article{citeulike:2639835, abstract = {We present ModuleMiner, a novel algorithm for computationally detecting cis-regulatory modules (CRMs) in a set of co-expressed genes. ModuleMiner outperforms other methods for CRM detection on benchmark data, and successfully detects CRMs in tissue-specific microarray clusters and in embryonic development gene sets. Interestingly, CRM predictions for differentiated tissues exhibit strong enrichment close to the transcription start site, whereas CRM predictions for embryonic development gene sets are depleted in this region.}, author = {Van Loo, Peter and Aerts, Stein and Thienpont, Bernard and De Moor, Bart and Moreau, Yves and Marynen, Peter}, citeulike-article-id = {2639835}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/gb-2008-9-4-r66}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18394174}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18394174}, doi = {10.1186/gb-2008-9-4-r66}, issn = {1465-6906}, journal = {Genome Biology}, number = {4}, pages = {R66+}, posted-at = {2008-04-09 08:36:24}, priority = {2}, title = {ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues?}, url = {http://dx.doi.org/10.1186/gb-2008-9-4-r66}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2639835 L3 - citeulike-article-id:2639835 N2 - We present ModuleMiner, a novel algorithm for computationally detecting cis-regulatory modules (CRMs) in a set of co-expressed genes. ModuleMiner outperforms other methods for CRM detection on benchmark data, and successfully detects CRMs in tissue-specific microarray clusters and in embryonic development gene sets. Interestingly, CRM predictions for differentiated tissues exhibit strong enrichment close to the transcription start site, whereas CRM predictions for embryonic development gene sets are depleted in this region. IS - 4 JF - Genome Biology SN - 1465-6906 TI - ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues? VL - 9 SP - R66 AU - Van Loo, Peter AU - Aerts, Stein AU - Thienpont, Bernard AU - De Moor, Bart AU - Moreau, Yves AU - Marynen, Peter PY - 2008/// UR - http://dx.doi.org/10.1186/gb-2008-9-4-r66 ER -