The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species. Export

@article{citeulike:5044135, abstract = {The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content.}, author = {{Reference Genome Group of the Gene Ontology Consortium}}, citeulike-article-id = {5044135}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pcbi.1000431}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19578431}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19578431}, day = {3}, doi = {10.1371/journal.pcbi.1000431}, issn = {1553-7358}, journal = {PLoS computational biology}, keywords = {db, mod, ontology}, month = {July}, number = {7}, pages = {e1000431+}, posted-at = {2009-07-27 08:53:38}, priority = {2}, publisher = {Public Library of Science}, title = {The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.}, url = {http://dx.doi.org/10.1371/journal.pcbi.1000431}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5044135 L3 - citeulike-article-id:5044135 N2 - The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content. IS - 7 JF - PLoS computational biology SN - 1553-7358 TI - The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species. PB - Public Library of Science VL - 5 SP - e1000431 KW - db KW - mod KW - ontology PY - 2009/07/03/ UR - http://dx.doi.org/10.1371/journal.pcbi.1000431 ER -