Sense from sequence reads: methods for alignment and assembly Export

@article{citeulike:6043667, abstract = {The most important first step in understanding next-generation sequencing data is the initial alignment or assembly that determines whether an experiment has succeeded and provides a first glimpse into the results. In parallel with the growth of new sequencing technologies, several algorithms that align or assemble the large data output of today's sequencing machines have been developed. We discuss the current algorithmic approaches and future directions of these fundamental tools and provide specific examples for some commonly used tools.}, author = {Flicek, Paul and Birney, Ewan}, citeulike-article-id = {6043667}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nmeth.1376}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nmeth.1376}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19844229}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19844229}, day = {15}, doi = {10.1038/nmeth.1376}, issn = {1548-7091}, journal = {Nature Methods}, keywords = {alignment, mapping, ngs}, month = {October}, number = {11s}, pages = {S6--S12}, posted-at = {2009-11-04 07:31:37}, priority = {2}, publisher = {Nature Publishing Group}, title = {Sense from sequence reads: methods for alignment and assembly}, url = {http://dx.doi.org/10.1038/nmeth.1376}, volume = {6}, year = {2009} }

TY - JOUR ID - citeulike:6043667 L3 - citeulike-article-id:6043667 N2 - The most important first step in understanding next-generation sequencing data is the initial alignment or assembly that determines whether an experiment has succeeded and provides a first glimpse into the results. In parallel with the growth of new sequencing technologies, several algorithms that align or assemble the large data output of today's sequencing machines have been developed. We discuss the current algorithmic approaches and future directions of these fundamental tools and provide specific examples for some commonly used tools. IS - 11s JF - Nature Methods SN - 1548-7091 EP - S12 TI - Sense from sequence reads: methods for alignment and assembly PB - Nature Publishing Group VL - 6 SP - S6 KW - alignment KW - mapping KW - ngs AU - Flicek, Paul AU - Birney, Ewan PY - 2009/10/15/ UR - http://dx.doi.org/10.1038/nmeth.1376 ER -