Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
by: Manuel A. Ferreira, Michael C. O'Donovan, Yan A. Meng, Ian R. Jones, Douglas M. Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H. Perlis, Elaine K. Green, Jordan W. Smoller, Detelina Grozeva, Jennifer Stone, Ivan Nikolov, Kimberly Chambert, Marian L. Hamshere, Vishwajit L. Nimgaonkar, Valentina Moskvina, Michael E. Thase, Sian Caesar, Gary S. Sachs, Jennifer Franklin, Katherine Gordon-Smith, Kristin G. Ardlie, Stacey B. Gabriel, Christine Fraser, Brendan Blumenstiel, Matthew Defelice, Gerome Breen, Michael Gill, Derek W. Morris, Amanda Elkin, Walter J. Muir, Kevin A. McGhee, Richard Williamson, Donald J. MacIntyre, Alan W. MacLean, Clair David D. St, Michelle Robinson, Margaret Van Beck, Ana C. Pereira, Radhika Kandaswamy, Andrew McQuillin, David A. Collier, Nicholas J. Bass, Allan H. Young, Jacob Lawrence, I. Nicol Ferrier, Adebayo Anjorin, Anne Farmer, David Curtis, Edward M. Scolnick, Peter McGuffin, Mark J. Daly, Aiden P. Corvin, Peter A. Holmans, Douglas H. Blackwood, Hugh M. Gurling, Michael J. Owen, Shaun M. Purcell, Pamela Sklar, Nick Craddock, Wellcome Trust Case Control Consortium
Nature genetics, Vol. 40, No. 9. (17 September 2008), pp. 1056-1058, doi:10.1038/ng.209 Key: citeulike:3168287
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Abstract
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
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