Protein Disorder Is Positively Correlated with Gene Expression in Escherichia coli

@article{citeulike:2774543, abstract = {Abstract: We considered, on a global scale, the relationship between the predicted fraction of protein disorder and the RNA and protein expression in Escherichia coli. Fraction of protein disorder correlated positively with both measured RNA expression levels of E. coli genes in three different growth media and with predicted abundance levels of E. coli proteins. Though weak, the correlation was highly significant. Correlation of protein disorder with RNA expression did not depend on the growth rate of E. coli cultures and was not caused by a small subset of genes showing exceptionally high concordance in their disorder and expression levels. Global analysis was complemented by detailed consideration of several groups of proteins.}, address = {Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio 45435, Center for Computational Biology and Bioinformatics and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, and Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia}, author = {Paliy, Oleg and Gargac, Shawn M. and Cheng, Yugong and Uversky, Vladimir N. and Dunker, Keith A. }, citeulike-article-id = {2774543}, doi = {10.1021/pr800055r}, journal = {J. Proteome Res.}, keywords = {disorder, ecoli, expression, protein, structure}, month = {May}, posted-at = {2008-05-09 07:51:04}, priority = {2}, title = {Protein Disorder Is Positively Correlated with Gene Expression in Escherichia coli}, url = {http://dx.doi.org/10.1021/pr800055r}, year = {2008} }

TY - JOUR ID - citeulike:2774543 L3 - citeulike-article-id:2774543 TI - Protein Disorder Is Positively Correlated with Gene Expression in Escherichia coli JF - J. Proteome Res. AD - Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio 45435, Center for Computational Biology and Bioinformatics and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, and Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia N2 - Abstract: We considered, on a global scale, the relationship between the predicted fraction of protein disorder and the RNA and protein expression in Escherichia coli. Fraction of protein disorder correlated positively with both measured RNA expression levels of E. coli genes in three different growth media and with predicted abundance levels of E. coli proteins. Though weak, the correlation was highly significant. Correlation of protein disorder with RNA expression did not depend on the growth rate of E. coli cultures and was not caused by a small subset of genes showing exceptionally high concordance in their disorder and expression levels. Global analysis was complemented by detailed consideration of several groups of proteins. KW - disorder KW - ecoli KW - expression KW - protein KW - structure AU - Paliy, Oleg AU - Gargac, Shawn AU - Cheng, Yugong AU - Uversky, Vladimir AU - Dunker, Keith PY - 2008/05/09/ UR - http://dx.doi.org/10.1021/pr800055r ER -