A genomic analysis of the archaeal system Ignicoccus hospitalis: Nanoarchaeum equitans Export

@article{citeulike:3501966, abstract = {BACKGROUND:The relationship between the hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans is the only known example of a specific association between two species of Archaea. Little is known about the mechanisms that enable this relationship. RESULTS:Here we sequenced the complete genome of I. hospitalis and found it to be the smallest among independent, free-living organisms. A comparative genomic reconstruction suggests that I. hospitalis lineage has lost most of the genes associated with a heterotrophic metabolism that is characteristic of most of the Crenarchaeota. A streamlined genome is also suggested by a low frequency of paralogs and fragmentation of many operons. However, this process appears to be partially balanced by lateral gene transfer from archaeal and bacterial sources. CONCLUSIONS:A combination of genomic and cellular features suggests highly efficient adaptation to the low energy yield of sulfur-hydrogen respiration and efficient inorganic carbon and nitrogen assimilation. Evidence of lateral gene exchange between N. equitans and I. hospitalis indicates that the relationship has impacted both genomes. This association is the simplest symbiotic system known to date and a unique model for studying mechanisms of interspecific relationships at the genomic and metabolic levels.}, author = {Podar, Mircea and Anderson, Iain and Makarova, Kira and Elkins, James and Ivanova, Natalia and Wall, Mark and Lykidis, Athanasios and Mavrommatis, Konstantinos and Sun, Hui and Hudson, Matthew and Chen, Wenqiong and Deciu, Cosmin and Hutchison, Don and Eads, Jonathan and Anderson, Abraham and Fernandes, Fillipe and Szeto, Ernest and Lapidus, Alla and Kyrpides, Nikos and Saier, Milton and Richardson, Paul and Rachel, Reinhard and Huber, Harald and Eisen, Jonathan and Koonin, Eugene and Keller, Martin and Stetter, Karl}, citeulike-article-id = {3501966}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/gb-2008-9-11-r158}, doi = {10.1186/gb-2008-9-11-r158}, issn = {1465-6906}, journal = {Genome Biology}, keywords = {archaea, genomics, ignicoccus, nanoarcheum, sequence, symbiosis}, number = {11}, posted-at = {2008-11-10 23:37:29}, priority = {2}, title = {A genomic analysis of the archaeal system Ignicoccus hospitalis: Nanoarchaeum equitans}, url = {http://dx.doi.org/10.1186/gb-2008-9-11-r158}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:3501966 L3 - citeulike-article-id:3501966 N2 - BACKGROUND:The relationship between the hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans is the only known example of a specific association between two species of Archaea. Little is known about the mechanisms that enable this relationship. RESULTS:Here we sequenced the complete genome of I. hospitalis and found it to be the smallest among independent, free-living organisms. A comparative genomic reconstruction suggests that I. hospitalis lineage has lost most of the genes associated with a heterotrophic metabolism that is characteristic of most of the Crenarchaeota. A streamlined genome is also suggested by a low frequency of paralogs and fragmentation of many operons. However, this process appears to be partially balanced by lateral gene transfer from archaeal and bacterial sources. CONCLUSIONS:A combination of genomic and cellular features suggests highly efficient adaptation to the low energy yield of sulfur-hydrogen respiration and efficient inorganic carbon and nitrogen assimilation. Evidence of lateral gene exchange between N. equitans and I. hospitalis indicates that the relationship has impacted both genomes. This association is the simplest symbiotic system known to date and a unique model for studying mechanisms of interspecific relationships at the genomic and metabolic levels. IS - 11 JF - Genome Biology SN - 1465-6906 TI - A genomic analysis of the archaeal system Ignicoccus hospitalis: Nanoarchaeum equitans VL - 9 KW - archaea KW - genomics KW - ignicoccus KW - nanoarcheum KW - sequence KW - symbiosis AU - Podar, Mircea AU - Anderson, Iain AU - Makarova, Kira AU - Elkins, James AU - Ivanova, Natalia AU - Wall, Mark AU - Lykidis, Athanasios AU - Mavrommatis, Konstantinos AU - Sun, Hui AU - Hudson, Matthew AU - Chen, Wenqiong AU - Deciu, Cosmin AU - Hutchison, Don AU - Eads, Jonathan AU - Anderson, Abraham AU - Fernandes, Fillipe AU - Szeto, Ernest AU - Lapidus, Alla AU - Kyrpides, Nikos AU - Saier, Milton AU - Richardson, Paul AU - Rachel, Reinhard AU - Huber, Harald AU - Eisen, Jonathan AU - Koonin, Eugene AU - Keller, Martin AU - Stetter, Karl PY - 2008/// UR - http://dx.doi.org/10.1186/gb-2008-9-11-r158 ER -