Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies Export

@article{citeulike:5186417, abstract = {The recent advent of exon microarrays has made it possible to reveal differences in alternative splicing events on a global scale. We introduce a novel statistical procedure that takes full advantage of the probe-level information on Affymetrix exon arrays when detecting differential splicing between sample groups. In comparison to existing ranking methods, the procedure shows superior reproducibility and accuracy in distinguishing true biological findings from background noise in high agreement with experimental validations.}, author = {Laajala, Essi and Aittokallio, Tero and Lahesmaa, Riitta and Elo, Laura}, citeulike-article-id = {5186417}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/gb-2009-10-7-r77}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19607685}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19607685}, doi = {10.1186/gb-2009-10-7-r77}, issn = {1465-6906}, journal = {Genome Biology}, keywords = {affymetrix, differential, exon, microarray, splicing, statistics}, number = {7}, pages = {R77+}, posted-at = {2009-07-17 00:39:38}, priority = {2}, title = {Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies}, url = {http://dx.doi.org/10.1186/gb-2009-10-7-r77}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5186417 L3 - citeulike-article-id:5186417 N2 - The recent advent of exon microarrays has made it possible to reveal differences in alternative splicing events on a global scale. We introduce a novel statistical procedure that takes full advantage of the probe-level information on Affymetrix exon arrays when detecting differential splicing between sample groups. In comparison to existing ranking methods, the procedure shows superior reproducibility and accuracy in distinguishing true biological findings from background noise in high agreement with experimental validations. IS - 7 JF - Genome Biology SN - 1465-6906 TI - Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies VL - 10 SP - R77 KW - affymetrix KW - differential KW - exon KW - microarray KW - splicing KW - statistics AU - Laajala, Essi AU - Aittokallio, Tero AU - Lahesmaa, Riitta AU - Elo, Laura PY - 2009/// UR - http://dx.doi.org/10.1186/gb-2009-10-7-r77 ER -