Systems pharmacology and genome medicine: a future perspective. Export

@article{citeulike:5918744, abstract = {ABSTRACT: Genome medicine uses genomic information in the diagnosis of disease and in prescribing treatment. This transdisciplinary field brings together knowledge on the relationships between genetics, pathophysiology and pharmacology. Systems pharmacology aims to understand the actions and adverse effects of drugs by considering targets in the context of the biological networks in which they exist. Genome medicine forms the base on which systems pharmacology can develop. Experimental and computational approaches enable systems pharmacology to obtain holistic, mechanistic information on disease networks and drug responses, and to identify new drug targets and specific drug combinations. Network analyses of interactions involved in pathophysiology and drug response across various scales of organization, from molecular to organismal, will allow the integration of the systems-level understanding of drug action with genome medicine. The interface of the two fields will enable drug discovery for personalized medicine. Here we provide a perspective on the questions and approaches that drive the development of these new interrelated fields.}, author = {Wist, Aislyn D. and Berger, Seth I. and Iyengar, Ravi}, citeulike-article-id = {5918744}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/gm11}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19348698}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19348698}, day = {22}, doi = {10.1186/gm11}, issn = {1756-994X}, journal = {Genome medicine}, keywords = {genome\_medicine, pharmaceutical, pharmacology}, month = {January}, number = {1}, posted-at = {2009-10-10 10:58:45}, priority = {2}, title = {Systems pharmacology and genome medicine: a future perspective.}, url = {http://dx.doi.org/10.1186/gm11}, volume = {1}, year = {2009} }

TY - JOUR ID - citeulike:5918744 L3 - citeulike-article-id:5918744 N2 - ABSTRACT: Genome medicine uses genomic information in the diagnosis of disease and in prescribing treatment. This transdisciplinary field brings together knowledge on the relationships between genetics, pathophysiology and pharmacology. Systems pharmacology aims to understand the actions and adverse effects of drugs by considering targets in the context of the biological networks in which they exist. Genome medicine forms the base on which systems pharmacology can develop. Experimental and computational approaches enable systems pharmacology to obtain holistic, mechanistic information on disease networks and drug responses, and to identify new drug targets and specific drug combinations. Network analyses of interactions involved in pathophysiology and drug response across various scales of organization, from molecular to organismal, will allow the integration of the systems-level understanding of drug action with genome medicine. The interface of the two fields will enable drug discovery for personalized medicine. Here we provide a perspective on the questions and approaches that drive the development of these new interrelated fields. IS - 1 JF - Genome medicine SN - 1756-994X TI - Systems pharmacology and genome medicine: a future perspective. VL - 1 KW - genome_medicine KW - pharmaceutical KW - pharmacology AU - Wist, Aislyn AU - Berger, Seth AU - Iyengar, Ravi PY - 2009/01/22/ UR - http://dx.doi.org/10.1186/gm11 ER -