Neural basis of the cognitive map: Path integration does not require hippocampus or entorhinal cortex Export

@article{citeulike:3138023, abstract = {10.1073/pnas.0805414105 The hippocampus and entorhinal cortex have been linked to both memory functions and to spatial cognition, but it has been unclear how these ideas relate to each other. An important part of spatial cognition is the ability to keep track of a reference location using self-motion cues (sometimes referred to as path integration), and it has been suggested that the hippocampus or entorhinal cortex is essential for this ability. Patients with hippocampal lesions or larger lesions that also included entorhinal cortex were led on paths while blindfolded (up to 15 m in length) and were asked to actively maintain the path in mind. Patients pointed to and estimated their distance from the start location as accurately as controls. A rotation condition confirmed that performance was based on self-motion cues. When demands on long-term memory were increased, patients were impaired. Thus, in humans, the hippocampus and entorhinal cortex are not essential for path integration.}, author = {Shrager, Yael and Kirwan, C. Brock and Squire, Larry R.}, citeulike-article-id = {3138023}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0805414105}, citeulike-linkout-1 = {http://www.pnas.org/content/105/33/12034.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/105/33/12034.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18687893}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18687893}, day = {19}, doi = {10.1073/pnas.0805414105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {ec, hippocampus, human, lesion, memory, path\_integration}, month = {August}, number = {33}, pages = {12034--12038}, posted-at = {2009-10-19 09:20:10}, priority = {2}, title = {Neural basis of the cognitive map: Path integration does not require hippocampus or entorhinal cortex}, url = {http://dx.doi.org/10.1073/pnas.0805414105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3138023 L3 - citeulike-article-id:3138023 N2 - 10.1073/pnas.0805414105 The hippocampus and entorhinal cortex have been linked to both memory functions and to spatial cognition, but it has been unclear how these ideas relate to each other. An important part of spatial cognition is the ability to keep track of a reference location using self-motion cues (sometimes referred to as path integration), and it has been suggested that the hippocampus or entorhinal cortex is essential for this ability. Patients with hippocampal lesions or larger lesions that also included entorhinal cortex were led on paths while blindfolded (up to 15 m in length) and were asked to actively maintain the path in mind. Patients pointed to and estimated their distance from the start location as accurately as controls. A rotation condition confirmed that performance was based on self-motion cues. When demands on long-term memory were increased, patients were impaired. Thus, in humans, the hippocampus and entorhinal cortex are not essential for path integration. IS - 33 JF - Proceedings of the National Academy of Sciences EP - 12038 TI - Neural basis of the cognitive map: Path integration does not require hippocampus or entorhinal cortex VL - 105 SP - 12034 KW - ec KW - hippocampus KW - human KW - lesion KW - memory KW - path_integration AU - Shrager, Yael AU - Kirwan, Brock AU - Squire, Larry PY - 2008/08/19/ UR - http://dx.doi.org/10.1073/pnas.0805414105 ER -