Fast synaptic subcortical control of hippocampal circuits. Export

@article{citeulike:5949719, abstract = {Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it is currently unknown if any such form of subcortical control exists. Here, we present direct evidence of a strong, spatiotemporally precise excitatory input from an ascending neuromodulatory center. Selective stimulation of serotonergic median raphe neurons produced a rapid activation of hippocampal interneurons. At the network level, this subcortical drive was manifested as a pattern of effective disynaptic GABAergic inhibition that spread throughout the circuit. This form of subcortical network regulation should be incorporated into current concepts of normal and pathological cortical function.}, author = {Varga, Viktor and Losonczy, Attila and Zemelman, Boris V. and Borhegyi, Zsolt and Nyiri, G\'{a}bor and Domonkos, Andor and Hangya, Bal\'{a}zs and Holderith, No\'{e}mi and Magee, Jeffrey C. and Freund, Tam\'{a}s F.}, citeulike-article-id = {5949719}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1178307}, citeulike-linkout-1 = {http://www.sciencemag.org/content/326/5951/449.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/326/5951/449.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19833972}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19833972}, day = {16}, doi = {10.1126/science.1178307}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {hippocampus, interneurons, serotonin}, month = {October}, number = {5951}, pages = {449--453}, posted-at = {2009-10-18 08:53:23}, priority = {2}, title = {Fast synaptic subcortical control of hippocampal circuits.}, url = {http://dx.doi.org/10.1126/science.1178307}, volume = {326}, year = {2009} }

TY - JOUR ID - citeulike:5949719 L3 - citeulike-article-id:5949719 N2 - Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it is currently unknown if any such form of subcortical control exists. Here, we present direct evidence of a strong, spatiotemporally precise excitatory input from an ascending neuromodulatory center. Selective stimulation of serotonergic median raphe neurons produced a rapid activation of hippocampal interneurons. At the network level, this subcortical drive was manifested as a pattern of effective disynaptic GABAergic inhibition that spread throughout the circuit. This form of subcortical network regulation should be incorporated into current concepts of normal and pathological cortical function. IS - 5951 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 453 TI - Fast synaptic subcortical control of hippocampal circuits. VL - 326 SP - 449 KW - hippocampus KW - interneurons KW - serotonin AU - Varga, Viktor AU - Losonczy, Attila AU - Zemelman, Boris AU - Borhegyi, Zsolt AU - Nyiri, Gábor AU - Domonkos, Andor AU - Hangya, Balázs AU - Holderith, Noémi AU - Magee, Jeffrey AU - Freund, Tamás PY - 2009/10/16/ UR - http://dx.doi.org/10.1126/science.1178307 ER -