Dendritic Compartment and Neuronal Output Mode Determine Pathway-Specific Long-Term Potentiation in the Piriform Cortex Export

@article{citeulike:6067074, abstract = {The apical dendrite of layer 2/3 pyramidal cells in the piriform cortex receives two spatially distinct inputs: one projecting onto the distal apical dendrite in sensory layer 1a, the other targeting the proximal apical dendrite in layer 1b. We observe an expression gradient of A-type K+ channels that weakens the backpropagating action potential-mediated depolarization in layer 1a compared with layer 1b. We find that the pairing of presynaptic and postsynaptic firing leads to significantly smaller Ca2+ signals in the distal dendritic spines in layer 1a compared with the proximal spines in layer 1b. The consequence is a selective failure to induce long-term potentiation (LTP) in layer 1a, which can be rescued by pharmacological enhancement of action potential backpropagation. In contrast, LTP induction by pairing presynaptic and postsynaptic firing is possible in layer 1b but requires bursting of the postsynaptic cell. This output mode strongly depends on the balance of excitation and inhibition in the piriform cortex. We show, on the single-spine level, how the plasticity of functionally distinct synapses is gated by the intrinsic electrical properties of piriform cortex layer 2 pyramidal cell dendrites and the cellular output mode. 10.1523/JNEUROSCI.2672-09.2009}, author = {Johenning, Friedrich W. and Beed, Prateep S. and Trimbuch, Thorsten and Bendels, Michael H. K. and Winterer, Jochen and Schmitz, Dietmar}, citeulike-article-id = {6067074}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.2672-09.2009}, citeulike-linkout-1 = {http://www.jneurosci.org/content/29/43/13649.abstract}, citeulike-linkout-2 = {http://www.jneurosci.org/content/29/43/13649.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19864577}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19864577}, day = {28}, doi = {10.1523/JNEUROSCI.2672-09.2009}, journal = {J. Neurosci.}, keywords = {bap, calcium\_imaging, ltp, piriform\_cortex}, month = {October}, number = {43}, pages = {13649--13661}, posted-at = {2009-11-04 09:12:42}, priority = {2}, title = {Dendritic Compartment and Neuronal Output Mode Determine Pathway-Specific Long-Term Potentiation in the Piriform Cortex}, url = {http://dx.doi.org/10.1523/JNEUROSCI.2672-09.2009}, volume = {29}, year = {2009} }

TY - JOUR ID - citeulike:6067074 L3 - citeulike-article-id:6067074 N2 - The apical dendrite of layer 2/3 pyramidal cells in the piriform cortex receives two spatially distinct inputs: one projecting onto the distal apical dendrite in sensory layer 1a, the other targeting the proximal apical dendrite in layer 1b. We observe an expression gradient of A-type K+ channels that weakens the backpropagating action potential-mediated depolarization in layer 1a compared with layer 1b. We find that the pairing of presynaptic and postsynaptic firing leads to significantly smaller Ca2+ signals in the distal dendritic spines in layer 1a compared with the proximal spines in layer 1b. The consequence is a selective failure to induce long-term potentiation (LTP) in layer 1a, which can be rescued by pharmacological enhancement of action potential backpropagation. In contrast, LTP induction by pairing presynaptic and postsynaptic firing is possible in layer 1b but requires bursting of the postsynaptic cell. This output mode strongly depends on the balance of excitation and inhibition in the piriform cortex. We show, on the single-spine level, how the plasticity of functionally distinct synapses is gated by the intrinsic electrical properties of piriform cortex layer 2 pyramidal cell dendrites and the cellular output mode. 10.1523/JNEUROSCI.2672-09.2009 IS - 43 JF - J. Neurosci. EP - 13661 TI - Dendritic Compartment and Neuronal Output Mode Determine Pathway-Specific Long-Term Potentiation in the Piriform Cortex VL - 29 SP - 13649 KW - bap KW - calcium_imaging KW - ltp KW - piriform_cortex AU - Johenning, Friedrich AU - Beed, Prateep AU - Trimbuch, Thorsten AU - Bendels, Michael AU - Winterer, Jochen AU - Schmitz, Dietmar PY - 2009/10/28/ UR - http://dx.doi.org/10.1523/JNEUROSCI.2672-09.2009 ER -