Neurodegeneration in Multiple Sclerosis: Relationship to Neurological Disability Export

@article{citeulike:5789089, abstract = {Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Most MS patients follow a relapsing-remitting course (RR-MS) for 8 to 15 years that transforms into a secondary progressive disease course (SP-MS). In this review, we discuss current data that describe MS as a neurodegenerative disease in which axonal loss is the major cause of irreversible neurological disability in MS patients. Neurological deficits in MS patients have two pathogeneses: acute inflammatory demyelination and axonal degeneration. Disability caused by inflammatory demyelination clinically dominates the early stages of RR-MS and is reversible. Axonal transection occurs at sites of inflammation and begins at disease onset but is clinically silent in RR-MS because the CNS compensates for neuronal loss. Once a threshold of axon loss is ex ceeded, MS patients enter an irreversible secondary progressive stage. In SP-MS, axonal degeneration is caused by chronic demyelination and may be irreversibly progressive. This view of MS provides a concep tional framework that explains conversion of RR-MS to SP-MS and provides a rationale for early aggressive anti-inflammatory and neuroprotective therapies. NEUROSCIENTIST 5:48-57, 1999 10.1177/107385849900500107}, author = {Trapp, Bruce D. and Ransohoff, Richard M. and Fisher, Elizabeth and Rudick, Richard A.}, citeulike-article-id = {5789089}, citeulike-linkout-0 = {http://dx.doi.org/10.1177/107385849900500107}, citeulike-linkout-1 = {http://nro.sagepub.com/cgi/content/abstract/5/1/48}, day = {1}, doi = {10.1177/107385849900500107}, journal = {Neuroscientist}, keywords = {atrophy, axons, ms}, month = {January}, number = {1}, pages = {48--57}, posted-at = {2009-09-15 19:41:04}, priority = {2}, title = {Neurodegeneration in Multiple Sclerosis: Relationship to Neurological Disability}, url = {http://dx.doi.org/10.1177/107385849900500107}, volume = {5}, year = {1999} }

TY - JOUR ID - citeulike:5789089 L3 - citeulike-article-id:5789089 N2 - Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Most MS patients follow a relapsing-remitting course (RR-MS) for 8 to 15 years that transforms into a secondary progressive disease course (SP-MS). In this review, we discuss current data that describe MS as a neurodegenerative disease in which axonal loss is the major cause of irreversible neurological disability in MS patients. Neurological deficits in MS patients have two pathogeneses: acute inflammatory demyelination and axonal degeneration. Disability caused by inflammatory demyelination clinically dominates the early stages of RR-MS and is reversible. Axonal transection occurs at sites of inflammation and begins at disease onset but is clinically silent in RR-MS because the CNS compensates for neuronal loss. Once a threshold of axon loss is ex ceeded, MS patients enter an irreversible secondary progressive stage. In SP-MS, axonal degeneration is caused by chronic demyelination and may be irreversibly progressive. This view of MS provides a concep tional framework that explains conversion of RR-MS to SP-MS and provides a rationale for early aggressive anti-inflammatory and neuroprotective therapies. NEUROSCIENTIST 5:48-57, 1999 10.1177/107385849900500107 IS - 1 JF - Neuroscientist EP - 57 TI - Neurodegeneration in Multiple Sclerosis: Relationship to Neurological Disability VL - 5 SP - 48 KW - atrophy KW - axons KW - ms AU - Trapp, Bruce AU - Ransohoff, Richard AU - Fisher, Elizabeth AU - Rudick, Richard PY - 1999/01/01/ UR - http://dx.doi.org/10.1177/107385849900500107 ER -