Shaping the zebrafish notochord Export

@article{citeulike:6081403, abstract = {Promptly after the notochord domain is specified in the vertebrate dorsal mesoderm, it undergoes dramatic morphogenesis. Beginning during gastrulation, convergence and extension movements change a squat cellular array into a narrow, elongated one that defines the primary axis of the embryo. Convergence and extension might be coupled by a highly organized cellular intermixing known as mediolateral intercalation behavior (MIB). To learn whether MIB drives early morphogenesis of the zebrafish notochord, we made 4D recordings and quantitatively analyzed both local cellular interactions and global changes in the shape of the dorsal mesodermal field. We show that MIB appears to mediate convergence and can account for extension throughout the dorsal mesoderm. Comparing the notochord and adjacent somitic mesoderm reveals that extension can be regulated separately from convergence. Moreover, mutational analysis shows that extension does not require convergence. Hence, a cellular machine separate from MIB that can drive dorsal mesodermal extension exists in the zebrafish gastrula. The likely redundant control of morphogenesis may provide for plasticity at this critical stage of early development. 10.1242/dev.00314}, author = {Glickman, Nathalia S. and Kimmel, Charles B. and Jones, Martha A. and Adams, Richard J.}, citeulike-article-id = {6081403}, citeulike-linkout-0 = {http://dx.doi.org/10.1242/dev.00314}, citeulike-linkout-1 = {http://dev.biologists.org/content/130/5/873.abstract}, citeulike-linkout-2 = {http://dev.biologists.org/content/130/5/873.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/12538515}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=12538515}, day = {1}, doi = {10.1242/dev.00314}, journal = {Development}, keywords = {development, gastrulation, zerbrafish}, month = {March}, number = {5}, pages = {873--887}, posted-at = {2009-11-06 18:39:03}, priority = {2}, title = {Shaping the zebrafish notochord}, url = {http://dx.doi.org/10.1242/dev.00314}, volume = {130}, year = {2003} }

TY - JOUR ID - citeulike:6081403 L3 - citeulike-article-id:6081403 N2 - Promptly after the notochord domain is specified in the vertebrate dorsal mesoderm, it undergoes dramatic morphogenesis. Beginning during gastrulation, convergence and extension movements change a squat cellular array into a narrow, elongated one that defines the primary axis of the embryo. Convergence and extension might be coupled by a highly organized cellular intermixing known as mediolateral intercalation behavior (MIB). To learn whether MIB drives early morphogenesis of the zebrafish notochord, we made 4D recordings and quantitatively analyzed both local cellular interactions and global changes in the shape of the dorsal mesodermal field. We show that MIB appears to mediate convergence and can account for extension throughout the dorsal mesoderm. Comparing the notochord and adjacent somitic mesoderm reveals that extension can be regulated separately from convergence. Moreover, mutational analysis shows that extension does not require convergence. Hence, a cellular machine separate from MIB that can drive dorsal mesodermal extension exists in the zebrafish gastrula. The likely redundant control of morphogenesis may provide for plasticity at this critical stage of early development. 10.1242/dev.00314 IS - 5 JF - Development EP - 887 TI - Shaping the zebrafish notochord VL - 130 SP - 873 KW - development KW - gastrulation KW - zerbrafish AU - Glickman, Nathalia AU - Kimmel, Charles AU - Jones, Martha AU - Adams, Richard PY - 2003/03/01/ UR - http://dx.doi.org/10.1242/dev.00314 ER -