Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR study. Export

@article{dunne05, abstract = {Following subarachnoid haemorrhage the most significant complication is sustained cerebral vascular contraction (vasospasm), which may result in terminal brain damage from cerebral infarction. Despite this, the biochemical cause of vasospasm remains poorly understood. In this study, the global high-concentration metabolite composition of CSF has been correlated with patient outcome after subarachnoid haemorrhage using multivariate statistics and 1H NMR spectroscopy. In total, 16 patients with aneurysmal subarachnoid haemorrhage (aSAH) were compared with 16 control patients who required a procedure where CSF was obtained but did not have aSAH. Multivariate statistics readily distinguished the aSAH group from the heterogeneous control group, even when only those controls with blood contamination in the CSF were used. Using principal components analysis and orthogonal signal correction, vasospasm was correlated to the concentrations of lactate, glucose and glutamine. These pattern recognition models of the NMR data also predicted Glasgow Coma Score (54\% within +/- 1 of the actual score on a scale of 1-15 for the whole patient group), Hunt and Hess SAH severity score (88\% within +/- 1 of the actual score on a scale of 1-5 for the aSAH group) and cognitive outcome scores (78\% within +/- 3 of the actual score on a 100\% scale for the whole patient group). Thus, the approach allowed the prediction of outcome as well as confirming the presence of aSAH.}, author = {Dunne, Victoria G. and Bhattachayya, Shermina and Besser, Michael and Rae, Caroline and Griffin, Julian L.}, citeulike-article-id = {5919409}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/nbm.918}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15455468}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15455468}, doi = {10.1002/nbm.918}, issn = {0952-3480}, journal = {NMR in biomedicine}, keywords = {biomarker, nmr, nmr\_moltwin}, month = {February}, number = {1}, pages = {24--33}, posted-at = {2009-10-10 13:57:32}, priority = {2}, title = {Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR study.}, url = {http://dx.doi.org/10.1002/nbm.918}, volume = {18}, year = {2005} }

TY - JOUR ID - dunne05 L3 - citeulike-article-id:5919409 N2 - Following subarachnoid haemorrhage the most significant complication is sustained cerebral vascular contraction (vasospasm), which may result in terminal brain damage from cerebral infarction. Despite this, the biochemical cause of vasospasm remains poorly understood. In this study, the global high-concentration metabolite composition of CSF has been correlated with patient outcome after subarachnoid haemorrhage using multivariate statistics and 1H NMR spectroscopy. In total, 16 patients with aneurysmal subarachnoid haemorrhage (aSAH) were compared with 16 control patients who required a procedure where CSF was obtained but did not have aSAH. Multivariate statistics readily distinguished the aSAH group from the heterogeneous control group, even when only those controls with blood contamination in the CSF were used. Using principal components analysis and orthogonal signal correction, vasospasm was correlated to the concentrations of lactate, glucose and glutamine. These pattern recognition models of the NMR data also predicted Glasgow Coma Score (54% within +/- 1 of the actual score on a scale of 1-15 for the whole patient group), Hunt and Hess SAH severity score (88% within +/- 1 of the actual score on a scale of 1-5 for the aSAH group) and cognitive outcome scores (78% within +/- 3 of the actual score on a 100% scale for the whole patient group). Thus, the approach allowed the prediction of outcome as well as confirming the presence of aSAH. IS - 1 JF - NMR in biomedicine SN - 0952-3480 EP - 33 TI - Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR study. VL - 18 SP - 24 KW - biomarker KW - nmr KW - nmr_moltwin AU - Dunne, Victoria AU - Bhattachayya, Shermina AU - Besser, Michael AU - Rae, Caroline AU - Griffin, Julian PY - 2005/02// UR - http://dx.doi.org/10.1002/nbm.918 ER -