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Protein structure: geometry, topology and classification Export

Reports of Progress in Physics, Vol. 64 (April 2001), pp. 517-590.

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domain-classification geometric-hashing graph-theory machine-learning msa pattern review structure-classification surface topology

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The structural principals of proteins are reviewed and analysed from a geometric perspective with a view to revealing the underlying regularities in their construction. Computer methods for the automatic comparison and classification of these structures are then reviewed with an analysis of the statistical significance of comparing different shapes. Following an analysis of the current state of the classification of proteins, more abstract geometric and topological representations are explored, including the occurrence of knotted topologies. The review concludes with a consideration of the origin of higher-level symmetries in protein structure.


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