Place Cells, Grid Cells, and the Brain's Spatial Representation System

@article{citeulike:2567611, abstract = {More than three decades of research have demonstrated a role for hippocampal place cells in representation of the spatial environment in the brain. New studies have shown that place cells are part of a broader circuit for dynamic representation of self-location. A key component of this network is the entorhinal grid cells, which, by virtue of their tessellating firing fields, may provide the elements of a path integration-based neural map. Here we review how place cells and grid cells may form the basis for quantitative spatiotemporal representation of places, routes, and associated experiences during behavior and in memory. Because these cell types have some of the most conspicuous behavioral correlates among neurons in nonsensory cortical systems, and because their spatial firing structure reflects computations internally in the system, studies of the entorhinal-hippocampal representation system may offer considerable insight into general principles of cortical network dynamics. Expected final online publication date for the Annual Review of Neuroscience Volume 31 is June 16, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, author = {Moser, Edvard I. and Kropff, Emilio and Moser, May B. }, citeulike-article-id = {2567611}, doi = {10.1146/annurev.neuro.31.061307.090723}, journal = {Annual Review of Neuroscience}, keywords = {memory, place-cell, review, rodent}, number = {1}, posted-at = {2008-07-17 01:23:00}, priority = {3}, title = {Place Cells, Grid Cells, and the Brain's Spatial Representation System}, url = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.neuro.31.061307.090723}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:2567611 L3 - citeulike-article-id:2567611 TI - Place Cells, Grid Cells, and the Brain's Spatial Representation System JF - Annual Review of Neuroscience VL - 31 IS - 1 N2 - More than three decades of research have demonstrated a role for hippocampal place cells in representation of the spatial environment in the brain. New studies have shown that place cells are part of a broader circuit for dynamic representation of self-location. A key component of this network is the entorhinal grid cells, which, by virtue of their tessellating firing fields, may provide the elements of a path integration-based neural map. Here we review how place cells and grid cells may form the basis for quantitative spatiotemporal representation of places, routes, and associated experiences during behavior and in memory. Because these cell types have some of the most conspicuous behavioral correlates among neurons in nonsensory cortical systems, and because their spatial firing structure reflects computations internally in the system, studies of the entorhinal-hippocampal representation system may offer considerable insight into general principles of cortical network dynamics. Expected final online publication date for the Annual Review of Neuroscience Volume 31 is June 16, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. KW - memory KW - place-cell KW - review KW - rodent AU - Moser, Edvard AU - Kropff, Emilio AU - Moser, May PY - 2008/// UR - http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.neuro.31.061307.090723 ER -