Frontotemporal dementia: clinicopathological correlations. Export

@article{citeulike:5158360, abstract = {OBJECTIVE: Frontotemporal lobar degeneration (FTLD) is characterized by impairments in social, behavioral, and/or language function, but postmortem studies indicate that multiple neuropathological entities lead to FTLD. This study assessed whether specific clinical features predict the underlying pathology. METHODS: A clinicopathological correlation was performed on 90 consecutive patients with a pathological diagnosis of frontotemporal dementia and was compared with an additional 24 cases accrued during the same time period with a clinical diagnosis of FTLD, but with pathology not typically associated with frontotemporal dementia. RESULTS: Postmortem examination showed multiple pathologies including tauopathies (46\%), FTLD with ubiquitin-positive inclusions (29\%), and Alzheimer's disease (17\%). The pathological groups manifested some distinct demographic, clinical, and neuropsychological features, although these attributes showed only a statistical association with the underlying pathology. FTLD with ubiquitin-positive inclusions was more likely to present with both social and language dysfunction, and motor neuron disease was more likely to emerge in these patients. Tauopathies were more commonly associated with an extrapyramidal disorder. Alzheimer's disease was associated with relatively greater deficits in memory and executive function. INTERPRETATION: Clinical and neuropsychological features contribute to delineating the spectrum of pathology underlying a patient diagnosed with FTLD, but biomarkers are needed that, together with the clinical phenotype, can predict the underlying neuropathology.}, author = {Forman, M. S. and Farmer, J. and Johnson, J. K. and Clark, C. M. and Arnold, S. E. and Coslett, H. B. and Chatterjee, A. and Hurtig, H. I. and Karlawish, J. H. and Rosen, H. J. and Van Deerlin, V. and Lee, V. M. and Miller, B. L. and Trojanowski, J. Q. and Grossman, M.}, citeulike-article-id = {5158360}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/ana.20873}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16718704}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16718704}, doi = {10.1002/ana.20873}, issn = {0364-5134}, journal = {Annals of neurology}, keywords = {dementia, ftld, pathology, semantic\_dementia}, month = {June}, number = {6}, pages = {952--962}, posted-at = {2009-07-15 13:19:49}, priority = {2}, title = {Frontotemporal dementia: clinicopathological correlations.}, url = {http://dx.doi.org/10.1002/ana.20873}, volume = {59}, year = {2006} }

TY - JOUR ID - citeulike:5158360 L3 - citeulike-article-id:5158360 N2 - OBJECTIVE: Frontotemporal lobar degeneration (FTLD) is characterized by impairments in social, behavioral, and/or language function, but postmortem studies indicate that multiple neuropathological entities lead to FTLD. This study assessed whether specific clinical features predict the underlying pathology. METHODS: A clinicopathological correlation was performed on 90 consecutive patients with a pathological diagnosis of frontotemporal dementia and was compared with an additional 24 cases accrued during the same time period with a clinical diagnosis of FTLD, but with pathology not typically associated with frontotemporal dementia. RESULTS: Postmortem examination showed multiple pathologies including tauopathies (46%), FTLD with ubiquitin-positive inclusions (29%), and Alzheimer's disease (17%). The pathological groups manifested some distinct demographic, clinical, and neuropsychological features, although these attributes showed only a statistical association with the underlying pathology. FTLD with ubiquitin-positive inclusions was more likely to present with both social and language dysfunction, and motor neuron disease was more likely to emerge in these patients. Tauopathies were more commonly associated with an extrapyramidal disorder. Alzheimer's disease was associated with relatively greater deficits in memory and executive function. INTERPRETATION: Clinical and neuropsychological features contribute to delineating the spectrum of pathology underlying a patient diagnosed with FTLD, but biomarkers are needed that, together with the clinical phenotype, can predict the underlying neuropathology. IS - 6 JF - Annals of neurology SN - 0364-5134 EP - 962 TI - Frontotemporal dementia: clinicopathological correlations. VL - 59 SP - 952 KW - dementia KW - ftld KW - pathology KW - semantic_dementia AU - Forman, MS AU - Farmer, J AU - Johnson, JK AU - Clark, CM AU - Arnold, SE AU - Coslett, HB AU - Chatterjee, A AU - Hurtig, HI AU - Karlawish, JH AU - Rosen, HJ AU - Van Deerlin, V AU - Lee, VM AU - Miller, BL AU - Trojanowski, JQ AU - Grossman, M PY - 2006/06// UR - http://dx.doi.org/10.1002/ana.20873 ER -