Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making Export

@article{citeulike:6080149, abstract = {Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being rewarded for correct performance at trial end via a visual signal, at one of four anticipated financial levels. Prior to the procedure, participants received either placebo (saline), a dopamine agonist (levodopa), or an antagonist (haloperidol). Principal findings: higher anticipated reward improved tactile decisions. Visually signalled reward reactivated primary somatosensory cortex for the judged hand, more strongly for higher reward. After receiving a higher reward on one trial, somatosensory activations and decisions were enhanced on the next trial. These behavioural and neural effects were all enhanced by levodopa and attenuated by haloperidol, indicating dopaminergic dependency. Dopaminergic reward-related influences extend even to early somatosensory cortex and sensory decision-making.}, author = {Pleger, Burkhard and Ruff, Christian C. and Blankenburg, Felix and Kl\"{o}ppel, Stefan and Driver, Jon and Dolan, Raymond J.}, citeulike-article-id = {6080149}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pbio.1000164}, day = {28}, doi = {10.1371/journal.pbio.1000164}, journal = {PLoS Biol}, keywords = {dopamine, fmri, pharmacological, reward}, month = {July}, number = {7}, pages = {e1000164+}, posted-at = {2009-11-06 08:21:09}, priority = {2}, publisher = {Public Library of Science}, title = {Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making}, url = {http://dx.doi.org/10.1371/journal.pbio.1000164}, volume = {7}, year = {2009} }

TY - JOUR ID - citeulike:6080149 L3 - citeulike-article-id:6080149 N2 - Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being rewarded for correct performance at trial end via a visual signal, at one of four anticipated financial levels. Prior to the procedure, participants received either placebo (saline), a dopamine agonist (levodopa), or an antagonist (haloperidol). Principal findings: higher anticipated reward improved tactile decisions. Visually signalled reward reactivated primary somatosensory cortex for the judged hand, more strongly for higher reward. After receiving a higher reward on one trial, somatosensory activations and decisions were enhanced on the next trial. These behavioural and neural effects were all enhanced by levodopa and attenuated by haloperidol, indicating dopaminergic dependency. Dopaminergic reward-related influences extend even to early somatosensory cortex and sensory decision-making. IS - 7 JF - PLoS Biol TI - Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making PB - Public Library of Science VL - 7 SP - e1000164 KW - dopamine KW - fmri KW - pharmacological KW - reward AU - Pleger, Burkhard AU - Ruff, Christian AU - Blankenburg, Felix AU - Klöppel, Stefan AU - Driver, Jon AU - Dolan, Raymond PY - 2009/07/28/ UR - http://dx.doi.org/10.1371/journal.pbio.1000164 ER -