Opioids: cellular mechanisms of tolerance and physical dependence

@article{citeulike:1269703, abstract = {Morphine and other opioids are used and abused for their analgesic and rewarding properties. Tolerance to these effects develops over hours/days to weeks, as can physical and psychological dependence. Despite much investigation, the precise cellular mechanisms underlying opioid tolerance and dependence remain elusive. Recent studies examining [mu]-opioid receptor desensitization and trafficking have revealed several potential mechanisms for acute receptor regulation. Other studies have reported changes in many other proteins that develop during chronic opioid treatment or withdrawal and such changes may be partly responsible for the cellular and synaptic adaptations to prolonged opioid exposure. While these studies have added to our knowledge of the cellular processes participating in opioid tolerance and dependence, the challenge remains to integrate these observations into a coherent explanation of the complex changes observed in whole animals chronically exposed to opioids.}, author = {Bailey, Chris P. and Connor, Mark }, citeulike-article-id = {1269703}, journal = {Current Opinion in Pharmacology}, keywords = {opioid, review}, month = {February}, number = {1}, pages = {60--68}, posted-at = {2007-05-01 06:35:37}, priority = {4}, title = {Opioids: cellular mechanisms of tolerance and physical dependence}, url = {http://www.sciencedirect.com/science/article/B6W7F-4F29SH9-2/2/1ebedb1ae7085a59545346c2b0595b5e}, volume = {5}, year = {2005} }

TY - JOUR ID - citeulike:1269703 L3 - citeulike-article-id:1269703 TI - Opioids: cellular mechanisms of tolerance and physical dependence JF - Current Opinion in Pharmacology VL - 5 IS - 1 SP - 60 EP - 68 N2 - Morphine and other opioids are used and abused for their analgesic and rewarding properties. Tolerance to these effects develops over hours/days to weeks, as can physical and psychological dependence. Despite much investigation, the precise cellular mechanisms underlying opioid tolerance and dependence remain elusive. Recent studies examining [mu]-opioid receptor desensitization and trafficking have revealed several potential mechanisms for acute receptor regulation. Other studies have reported changes in many other proteins that develop during chronic opioid treatment or withdrawal and such changes may be partly responsible for the cellular and synaptic adaptations to prolonged opioid exposure. While these studies have added to our knowledge of the cellular processes participating in opioid tolerance and dependence, the challenge remains to integrate these observations into a coherent explanation of the complex changes observed in whole animals chronically exposed to opioids. KW - opioid KW - review AU - Bailey, Chris AU - Connor, Mark PY - 2005/02// UR - http://www.sciencedirect.com/science/article/B6W7F-4F29SH9-2/2/1ebedb1ae7085a59545346c2b0595b5e ER -