Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain Export

@article{citeulike:1359745, abstract = {Dobson CF, Tohyama Y, Diksic M \& Hamel E. Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain. Cephalalgia 2004; 24:2-11. London. ISSN 0333-1024 Triptans are 5-HT1 receptor agonists used as anti-migraine drugs. They act primarily on meningeal blood vessels and on trigeminovascular afferents, but they may also exert central effects. We studied the regional effects of acute and chronic treatment with sumatriptan or zolmitriptan on the rate of serotonin (5-HT) synthesis in the rat brain, using the alpha-14C-methyl-L-tryptophan quantitative autoradiographic method. Sumatriptan at low (300 ug/kg, s.c.) and high (1 mg/kg) doses, as well as zolmitriptan (100 ug/kg), acutely decreased (15-40\%, P < 0.05-0.001) 5-HT synthetic rate in many brain regions, including the dorsal raphe nucleus. Chronically, sumatriptan (21 days, approximately 300 ug/kg per day via osmotic minipumps) induced significant increases in the 5-HT synthesis rate in many projection areas but had no effect in the dorsal raphe nucleus. The acute effects on 5-HT synthesis rate would be compatible with activation of 5-HT1 autoreceptors that inhibit serotonin release. In contrast, the increased 5-HT synthesis rate observed after chronic sumatriptan might possibly result from a down-regulation/desensitization of 5-HT1 receptors and/or unmasking of excitatory triptan-sensitive 5-HT receptors. Overall, the present findings indicate that not only zolmitriptan but also sumatriptan affect brain serotonergic neurotransmission.}, author = {Dobson, Cf and Tohyama, Y. and Diksic, M. and Hamel, E.}, citeulike-article-id = {1359745}, citeulike-linkout-0 = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.1468-2982.2004.00647.x}, citeulike-linkout-1 = {http://dx.doi.org/10.1111/j.1468-2982.2004.00647.x}, doi = {10.1111/j.1468-2982.2004.00647.x}, journal = {Cephalalgia}, keywords = {migraine, serotonin}, number = {1}, pages = {2--11}, posted-at = {2007-06-03 07:07:56}, priority = {2}, title = {Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain}, url = {http://dx.doi.org/10.1111/j.1468-2982.2004.00647.x}, volume = {24}, year = {2004} }

TY - JOUR ID - citeulike:1359745 L3 - citeulike-article-id:1359745 N2 - Dobson CF, Tohyama Y, Diksic M & Hamel E. Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain. Cephalalgia 2004; 24:2-11. London. ISSN 0333-1024 Triptans are 5-HT1 receptor agonists used as anti-migraine drugs. They act primarily on meningeal blood vessels and on trigeminovascular afferents, but they may also exert central effects. We studied the regional effects of acute and chronic treatment with sumatriptan or zolmitriptan on the rate of serotonin (5-HT) synthesis in the rat brain, using the alpha-14C-methyl-L-tryptophan quantitative autoradiographic method. Sumatriptan at low (300 ug/kg, s.c.) and high (1 mg/kg) doses, as well as zolmitriptan (100 ug/kg), acutely decreased (15-40%, P < 0.05-0.001) 5-HT synthetic rate in many brain regions, including the dorsal raphe nucleus. Chronically, sumatriptan (21 days, approximately 300 ug/kg per day via osmotic minipumps) induced significant increases in the 5-HT synthesis rate in many projection areas but had no effect in the dorsal raphe nucleus. The acute effects on 5-HT synthesis rate would be compatible with activation of 5-HT1 autoreceptors that inhibit serotonin release. In contrast, the increased 5-HT synthesis rate observed after chronic sumatriptan might possibly result from a down-regulation/desensitization of 5-HT1 receptors and/or unmasking of excitatory triptan-sensitive 5-HT receptors. Overall, the present findings indicate that not only zolmitriptan but also sumatriptan affect brain serotonergic neurotransmission. IS - 1 JF - Cephalalgia EP - 11 TI - Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain VL - 24 SP - 2 KW - migraine KW - serotonin AU - Dobson, Cf AU - Tohyama, Y AU - Diksic, M AU - Hamel, E PY - 2004/// UR - http://dx.doi.org/10.1111/j.1468-2982.2004.00647.x ER -