Signaling pathways involved in the development of cannabinoid tolerance Export

@article{citeulike:1410040, abstract = {Considerable plasticity exists in the endogenous cannabinoid system, as evidenced by the high degree of tolerance that develops following repetitive exposure to exogenously administered cannabinoid receptor agonists. This tolerance development is accompanied by cannabinoid CB1 receptor downregulation and attenuation of G-protein activation. The biological processes responsible for CB1 receptor downregulation remain to be fully understood. However, recent evidence suggests that several protein kinases participate in the development of cannabinoid tolerance. These observations implicate a role for protein kinases in cannabinoid signaling pathways. It remains to be established whether these protein kinases are directly involved in CB1 receptor regulation or whether they contribute to tolerance by modulating additional signaling pathways.}, author = {Martin, Billy R. and Sim-Selley, Laura J. and Selley, Dana E.}, citeulike-article-id = {1410040}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tips.2004.04.005}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T1K-4C8P8N5-3/2/1254c0ba2a894b6337cb2221ef7ce62a}, doi = {10.1016/j.tips.2004.04.005}, journal = {Trends in Pharmacological Sciences}, keywords = {cannabinoid, gpcrs, tolerance}, month = {June}, number = {6}, pages = {325--330}, posted-at = {2007-06-25 04:00:26}, priority = {3}, title = {Signaling pathways involved in the development of cannabinoid tolerance}, url = {http://dx.doi.org/10.1016/j.tips.2004.04.005}, volume = {25}, year = {2004} }

TY - JOUR ID - citeulike:1410040 L3 - citeulike-article-id:1410040 N2 - Considerable plasticity exists in the endogenous cannabinoid system, as evidenced by the high degree of tolerance that develops following repetitive exposure to exogenously administered cannabinoid receptor agonists. This tolerance development is accompanied by cannabinoid CB1 receptor downregulation and attenuation of G-protein activation. The biological processes responsible for CB1 receptor downregulation remain to be fully understood. However, recent evidence suggests that several protein kinases participate in the development of cannabinoid tolerance. These observations implicate a role for protein kinases in cannabinoid signaling pathways. It remains to be established whether these protein kinases are directly involved in CB1 receptor regulation or whether they contribute to tolerance by modulating additional signaling pathways. IS - 6 JF - Trends in Pharmacological Sciences EP - 330 TI - Signaling pathways involved in the development of cannabinoid tolerance VL - 25 SP - 325 KW - cannabinoid KW - gpcrs KW - tolerance AU - Martin, Billy AU - Sim-Selley, Laura AU - Selley, Dana PY - 2004/06// UR - http://dx.doi.org/10.1016/j.tips.2004.04.005 ER -