P/Q-Type Calcium-Channel Blockade in the Periaqueductal Gray Facilitates Trigeminal Nociception: A Functional Genetic Link for Migraine? Export

@article{citeulike:2351688, abstract = {The discovery of mis-sense mutations in the [alpha]1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine. The periaqueductal gray (PAG) region of the brainstem modulates craniovascular nociception and, through its role in the descending pain modulation system, may contribute to migraine pathophysiology. In this study we sought to investigate the possible link between the genetic mutations found in migraineurs and the PAG as a modulator of craniovascular nociception. We microinjected the P/Q-type calcium-channel blocker [omega]-agatoxin IVA into the rat ventrolateral PAG (vlPAG). We examined its effect on the nociceptive transmission of second-order neurons recorded in the trigeminal nucleus caudalis and activated by stimulation of the parietal dura mater. After injection of agatoxin into the vlPAG (n = 20) responses to dural stimulation were facilitated by 143\% (p < 0.0001) for A[delta]-fiber activity and 180\% for C-fiber activity (p < 0.05). Similarly, spontaneous background activity increased by 163\% (p < 0.0001). These results demonstrate that P/Q-type calcium channels in the PAG play a role in modulating trigeminal nociception and suggest a role for dysfunctional P/Q-type calcium channels in migraine pathophysiology.}, author = {Knight, Yolande E. and Bartsch, Thorsten and Kaube, Holger and Goadsby, Peter J.}, citeulike-article-id = {2351688}, citeulike-linkout-0 = {http://www.jneurosci.org/cgi/content/abstract/22/5/RC213}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11880534}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11880534}, day = {1}, journal = {J. Neurosci.}, keywords = {calcium-channel, migraine, nociception, pag}, month = {March}, number = {5}, pages = {213RC+}, posted-at = {2008-02-08 02:30:56}, priority = {3}, title = {P/Q-Type Calcium-Channel Blockade in the Periaqueductal Gray Facilitates Trigeminal Nociception: A Functional Genetic Link for Migraine?}, url = {http://www.jneurosci.org/cgi/content/abstract/22/5/RC213}, volume = {22}, year = {2002} }

TY - JOUR ID - citeulike:2351688 L3 - citeulike-article-id:2351688 N2 - The discovery of mis-sense mutations in the [alpha]1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine. The periaqueductal gray (PAG) region of the brainstem modulates craniovascular nociception and, through its role in the descending pain modulation system, may contribute to migraine pathophysiology. In this study we sought to investigate the possible link between the genetic mutations found in migraineurs and the PAG as a modulator of craniovascular nociception. We microinjected the P/Q-type calcium-channel blocker [omega]-agatoxin IVA into the rat ventrolateral PAG (vlPAG). We examined its effect on the nociceptive transmission of second-order neurons recorded in the trigeminal nucleus caudalis and activated by stimulation of the parietal dura mater. After injection of agatoxin into the vlPAG (n = 20) responses to dural stimulation were facilitated by 143% (p < 0.0001) for A[delta]-fiber activity and 180% for C-fiber activity (p < 0.05). Similarly, spontaneous background activity increased by 163% (p < 0.0001). These results demonstrate that P/Q-type calcium channels in the PAG play a role in modulating trigeminal nociception and suggest a role for dysfunctional P/Q-type calcium channels in migraine pathophysiology. IS - 5 JF - J. Neurosci. TI - P/Q-Type Calcium-Channel Blockade in the Periaqueductal Gray Facilitates Trigeminal Nociception: A Functional Genetic Link for Migraine? VL - 22 SP - 213RC KW - calcium-channel KW - migraine KW - nociception KW - pag AU - Knight, Yolande AU - Bartsch, Thorsten AU - Kaube, Holger AU - Goadsby, Peter PY - 2002/03/01/ UR - http://www.jneurosci.org/cgi/content/abstract/22/5/RC213 ER -