Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Export

@article{citeulike:4285847, abstract = {Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors.}, author = {Bartlett, S. E. and Enquist, J. and Hopf, F. W. and Lee, J. H. and Gladher, F. and Kharazia, V. and Waldhoer, M. and Mailliard, W. S. and Armstrong, R. and Bonci, A. and Whistler, J. L.}, citeulike-article-id = {4285847}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0502418102}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16049099}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16049099}, day = {9}, doi = {10.1073/pnas.0502418102}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {dopamine, internalization, pathways}, month = {August}, number = {32}, pages = {11521--11526}, posted-at = {2009-04-08 08:40:56}, priority = {3}, title = {Dopamine responsiveness is regulated by targeted sorting of D2 receptors.}, url = {http://dx.doi.org/10.1073/pnas.0502418102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:4285847 L3 - citeulike-article-id:4285847 N2 - Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors. IS - 32 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 11526 TI - Dopamine responsiveness is regulated by targeted sorting of D2 receptors. VL - 102 SP - 11521 KW - dopamine KW - internalization KW - pathways AU - Bartlett, SE AU - Enquist, J AU - Hopf, FW AU - Lee, JH AU - Gladher, F AU - Kharazia, V AU - Waldhoer, M AU - Mailliard, WS AU - Armstrong, R AU - Bonci, A AU - Whistler, JL PY - 2005/08/09/ UR - http://dx.doi.org/10.1073/pnas.0502418102 ER -