Cluster-Buster: finding dense clusters of motifs in DNA sequences

@article{citeulike:2097474, abstract = {The signals that determine activation and repression of specific genes in response to appropriate stimuli are one of the most important, but least understood, types of information encoded in genomic DNA. The nucleotide sequence patterns, or motifs, preferentially bound by various transcription factors have been collected in databases. However, these motifs appear to be individually too short and degenerate to enable detection of functional enhancer and silencer elements within a large genome. Several groups have proposed that dense clusters of motifs may diagnose regulatory regions more accurately. Cluster-Buster is the third incarnation of our software for finding clusters of pre-specified motifs in DNA sequences. We offer a Cluster-Buster web server at http://zlab.bu.edu/cluster-buster/. 10.1093/nar/gkg540}, author = {Frith, Martin C. and Li, Michael C. and Weng, Zhiping}, citeulike-article-id = {2097474}, doi = {10.1093/nar/gkg540}, journal = {Nucl. Acids Res.}, keywords = {clustering, dna}, month = {July}, number = {13}, pages = {3666--3668}, posted-at = {2008-12-03 23:22:31}, priority = {2}, title = {Cluster-Buster: finding dense clusters of motifs in DNA sequences}, url = {http://dx.doi.org/10.1093/nar/gkg540}, volume = {31}, year = {2003} }

TY - JOUR ID - citeulike:2097474 L3 - citeulike-article-id:2097474 N2 - The signals that determine activation and repression of specific genes in response to appropriate stimuli are one of the most important, but least understood, types of information encoded in genomic DNA. The nucleotide sequence patterns, or motifs, preferentially bound by various transcription factors have been collected in databases. However, these motifs appear to be individually too short and degenerate to enable detection of functional enhancer and silencer elements within a large genome. Several groups have proposed that dense clusters of motifs may diagnose regulatory regions more accurately. Cluster-Buster is the third incarnation of our software for finding clusters of pre-specified motifs in DNA sequences. We offer a Cluster-Buster web server at http://zlab.bu.edu/cluster-buster/. 10.1093/nar/gkg540 IS - 13 JF - Nucl. Acids Res. EP - 3668 TI - Cluster-Buster: finding dense clusters of motifs in DNA sequences VL - 31 SP - 3666 KW - clustering KW - dna AU - Frith, Martin AU - Li, Michael AU - Weng, Zhiping PY - 2003/07/01/ UR - http://dx.doi.org/10.1093/nar/gkg540 ER -