High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study. Export

@article{citeulike:3519577, abstract = {OBJECTIVE: To assess the association between high but nondiabetic blood glucose levels and the risk of death from all causes, coronary heart disease (CHD), cardiovascular disease, and neoplasms. RESEARCH DESIGN AND METHODS: We studied the 20-year mortality of non-diabetic, working men, age 44-55 years, in three European cohorts known as the Whitehall Study (n = 10,025), the Paris Prospective Study (n = 6,629), and the Helsinki Policeman Study (n = 631). These men were identified by their 2-h glucose levels following an oral glucose tolerance test and by the absence of a prior diagnosis of diabetes. As the protocol for the oral glucose tolerance test and methods for measuring glucose differed between studies, mortality was analyzed according to the percentiles of the 2-h and fasting glucose distributions, using the Cox's proportional hazards model. RESULTS: Men in the upper 20\% of the 2-h glucose distributions and those in the upper 2.5\% for fasting glucose had a significantly higher risk of all-cause mortality in comparison with men in the lower 80\% of these distributions, with age-adjusted hazard ratios of 1.6 (95\% CI 1.4-1.9) and 2.0 (1.6-2.6) for the upper 2.5\%. For death from cardiovascular and CHD, men in the upper 2.5\% of the 2-h and fasting glucose distributions were at higher risk, with age-adjusted hazard ratios for CHD of 1.8 (1.4-2.4) and 2.7 (1.7-4.4), respectively. CONCLUSIONS: If early intervention aimed at lowering blood glucose concentrations can be shown to reduce mortality, it may be justified to lower the levels of both 2-h and fasting glucose, which define diabetes.}, author = {Balkau, B. and Shipley, M. and Jarrett, R. J. and Py\"{o}r\"{a}l\"{a}, K. and Py\"{o}r\"{a}l\"{a}, M. and Forhan, A. and Eschw\`{e}ge, E.}, citeulike-article-id = {3519577}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9540016}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9540016}, issn = {0149-5992}, journal = {Diabetes care}, keywords = {helsinkipol, independentriskfactor, paris, prospective, whitehallstudy}, month = {March}, number = {3}, pages = {360--367}, posted-at = {2008-11-15 21:22:17}, priority = {3}, title = {High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9540016}, volume = {21}, year = {1998} }

TY - JOUR ID - citeulike:3519577 L3 - citeulike-article-id:3519577 N2 - OBJECTIVE: To assess the association between high but nondiabetic blood glucose levels and the risk of death from all causes, coronary heart disease (CHD), cardiovascular disease, and neoplasms. RESEARCH DESIGN AND METHODS: We studied the 20-year mortality of non-diabetic, working men, age 44-55 years, in three European cohorts known as the Whitehall Study (n = 10,025), the Paris Prospective Study (n = 6,629), and the Helsinki Policeman Study (n = 631). These men were identified by their 2-h glucose levels following an oral glucose tolerance test and by the absence of a prior diagnosis of diabetes. As the protocol for the oral glucose tolerance test and methods for measuring glucose differed between studies, mortality was analyzed according to the percentiles of the 2-h and fasting glucose distributions, using the Cox's proportional hazards model. RESULTS: Men in the upper 20% of the 2-h glucose distributions and those in the upper 2.5% for fasting glucose had a significantly higher risk of all-cause mortality in comparison with men in the lower 80% of these distributions, with age-adjusted hazard ratios of 1.6 (95% CI 1.4-1.9) and 2.0 (1.6-2.6) for the upper 2.5%. For death from cardiovascular and CHD, men in the upper 2.5% of the 2-h and fasting glucose distributions were at higher risk, with age-adjusted hazard ratios for CHD of 1.8 (1.4-2.4) and 2.7 (1.7-4.4), respectively. CONCLUSIONS: If early intervention aimed at lowering blood glucose concentrations can be shown to reduce mortality, it may be justified to lower the levels of both 2-h and fasting glucose, which define diabetes. IS - 3 JF - Diabetes care SN - 0149-5992 EP - 367 TI - High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study. VL - 21 SP - 360 KW - helsinkipol KW - independentriskfactor KW - paris KW - prospective KW - whitehallstudy AU - Balkau, B AU - Shipley, M AU - Jarrett, RJ AU - Pyörälä, K AU - Pyörälä, M AU - Forhan, A AU - Eschwège, E PY - 1998/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/9540016 ER -