Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men. Export

@article{citeulike:3519580, abstract = {OBJECTIVE: Because of the available conflicting epidemiological data, we investigated the possible impact of fasting blood glucose as a risk factor for cardiovascular death in nondiabetic men. This study reports the results from a 22-year prospective study on fasting blood glucose as a predictor of cardiovascular death. RESEARCH DESIGN AND METHODS: Of the 1,998 apparently healthy nondiabetic men (aged 40-59 years), a total of 1,973 with fasting blood glucose < 110 mg/dl were included in the study in which also a number of conventional risk factors were measured at baseline. RESULTS: After 22 years of follow-up, 483 men had died, 53\% from cardiovascular diseases. After dividing men into quartiles of fasting blood glucose level, it was found that men in the highest glucose quartile (fasting blood glucose > 85 mg/dl) had a significantly higher mortality rate from cardiovascular diseases compared with those in the three lowest quartiles. Even after adjusting for age, smoking habits, serum lipids, blood pressure, forced expiratory volume in 1 s, and physical fitness (Cox model), the relative risk of cardiovascular death for men with fasting blood glucose > 85 mg/dl remained 1.4 (95\% CI 1.04-1.8). Noncardiovascular deaths were unrelated to fasting blood glucose level. CONCLUSIONS: Fasting blood glucose values in the upper normal range appears to be an important independent predictor of cardiovascular death in nondiabetic apparently healthy middle-aged men.}, author = {Bj{\o}rnholt, J. V. and Erikssen, G. and Aaser, E. and Sandvik, L. and Nitter-Hauge, S. and Jervell, J. and Erikssen, J. and Thaulow, E.}, citeulike-article-id = {3519580}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10333902}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10333902}, issn = {0149-5992}, journal = {Diabetes care}, keywords = {cvd, followup, riskfactor}, month = {January}, number = {1}, pages = {45--49}, posted-at = {2008-11-15 21:25:00}, priority = {2}, title = {Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10333902}, volume = {22}, year = {1999} }

TY - JOUR ID - citeulike:3519580 L3 - citeulike-article-id:3519580 N2 - OBJECTIVE: Because of the available conflicting epidemiological data, we investigated the possible impact of fasting blood glucose as a risk factor for cardiovascular death in nondiabetic men. This study reports the results from a 22-year prospective study on fasting blood glucose as a predictor of cardiovascular death. RESEARCH DESIGN AND METHODS: Of the 1,998 apparently healthy nondiabetic men (aged 40-59 years), a total of 1,973 with fasting blood glucose < 110 mg/dl were included in the study in which also a number of conventional risk factors were measured at baseline. RESULTS: After 22 years of follow-up, 483 men had died, 53% from cardiovascular diseases. After dividing men into quartiles of fasting blood glucose level, it was found that men in the highest glucose quartile (fasting blood glucose > 85 mg/dl) had a significantly higher mortality rate from cardiovascular diseases compared with those in the three lowest quartiles. Even after adjusting for age, smoking habits, serum lipids, blood pressure, forced expiratory volume in 1 s, and physical fitness (Cox model), the relative risk of cardiovascular death for men with fasting blood glucose > 85 mg/dl remained 1.4 (95% CI 1.04-1.8). Noncardiovascular deaths were unrelated to fasting blood glucose level. CONCLUSIONS: Fasting blood glucose values in the upper normal range appears to be an important independent predictor of cardiovascular death in nondiabetic apparently healthy middle-aged men. IS - 1 JF - Diabetes care SN - 0149-5992 EP - 49 TI - Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men. VL - 22 SP - 45 KW - cvd KW - followup KW - riskfactor AU - Bjørnholt, JV AU - Erikssen, G AU - Aaser, E AU - Sandvik, L AU - Nitter-Hauge, S AU - Jervell, J AU - Erikssen, J AU - Thaulow, E PY - 1999/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/10333902 ER -