Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease. Export

@article{citeulike:5489912, abstract = {Previously published data demonstrate clearly that hyperglycemia worsens morbidity and mortality in patients in intensive care, those with acute myocardial infarction and stroke, and those who undergo coronary artery bypass grafting. The control of hyperglycemia with insulin infusion improves clinical outcomes in all these classes of patients. In this report, the investigators discuss data demonstrating an anti-inflammatory effect of insulin and a proinflammatory effect of glucose and free fatty acids and provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusions in hospitalized patients. The regimens that infuse fixed doses of insulin with high rates of glucose are usually associated with hyperglycemia. This may neutralize the beneficial effects of insulin. Such regimens should therefore be avoided in the future and replaced by regimens that infuse insulin to restore and maintain euglycemia.}, author = {Dandona, Paresh and Chaudhuri, Ajay and Ghanim, Husam and Mohanty, Priya}, citeulike-article-id = {5489912}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.amjcard.2006.11.003}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17307055}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17307055}, day = {19}, doi = {10.1016/j.amjcard.2006.11.003}, issn = {0002-9149}, journal = {The American journal of cardiology}, keywords = {crp, cytokines, inflammatory, insulin, review}, month = {February}, number = {4A}, posted-at = {2009-08-20 14:32:37}, priority = {2}, title = {Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease.}, url = {http://dx.doi.org/10.1016/j.amjcard.2006.11.003}, volume = {99}, year = {2007} }

TY - JOUR ID - citeulike:5489912 L3 - citeulike-article-id:5489912 N2 - Previously published data demonstrate clearly that hyperglycemia worsens morbidity and mortality in patients in intensive care, those with acute myocardial infarction and stroke, and those who undergo coronary artery bypass grafting. The control of hyperglycemia with insulin infusion improves clinical outcomes in all these classes of patients. In this report, the investigators discuss data demonstrating an anti-inflammatory effect of insulin and a proinflammatory effect of glucose and free fatty acids and provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusions in hospitalized patients. The regimens that infuse fixed doses of insulin with high rates of glucose are usually associated with hyperglycemia. This may neutralize the beneficial effects of insulin. Such regimens should therefore be avoided in the future and replaced by regimens that infuse insulin to restore and maintain euglycemia. IS - 4A JF - The American journal of cardiology SN - 0002-9149 TI - Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease. VL - 99 KW - crp KW - cytokines KW - inflammatory KW - insulin KW - review AU - Dandona, Paresh AU - Chaudhuri, Ajay AU - Ghanim, Husam AU - Mohanty, Priya PY - 2007/02/19/ UR - http://dx.doi.org/10.1016/j.amjcard.2006.11.003 ER -