Insulin as an anti-inflammatory and antiatherogenic modulator. Export

@article{citeulike:5489917, abstract = {Data demonstrate the anti-inflammatory effects of insulin and proinflammatory effects of glucose. These data provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusions in hospitalized patients. Regimens that infuse fixed doses of insulin with high rates of glucose are usually associated with hyperglycemia, which may neutralize the beneficial effects of insulin. Therefore, we propose that such regimens should be avoided and instead replaced by insulin infusions that normalize and maintain blood glucose at a reasonably low level and ensure that plasma insulin is maintained at levels high enough to provide clinically relevant anti-inflammatory and cardioprotective effects. Trials to test this hypothesis are in progress.}, author = {Dandona, Paresh and Chaudhuri, Ajay and Ghanim, Husam and Mohanty, Priya}, citeulike-article-id = {5489917}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jacc.2008.10.038}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19179212}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19179212}, day = {3}, doi = {10.1016/j.jacc.2008.10.038}, issn = {1558-3597}, journal = {Journal of the American College of Cardiology}, keywords = {crp, cytokines, inflammation, inflammatory, insulin, review}, month = {February}, number = {5 Suppl}, posted-at = {2009-08-20 14:34:55}, priority = {2}, title = {Insulin as an anti-inflammatory and antiatherogenic modulator.}, url = {http://dx.doi.org/10.1016/j.jacc.2008.10.038}, volume = {53}, year = {2009} }

TY - JOUR ID - citeulike:5489917 L3 - citeulike-article-id:5489917 N2 - Data demonstrate the anti-inflammatory effects of insulin and proinflammatory effects of glucose. These data provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusions in hospitalized patients. Regimens that infuse fixed doses of insulin with high rates of glucose are usually associated with hyperglycemia, which may neutralize the beneficial effects of insulin. Therefore, we propose that such regimens should be avoided and instead replaced by insulin infusions that normalize and maintain blood glucose at a reasonably low level and ensure that plasma insulin is maintained at levels high enough to provide clinically relevant anti-inflammatory and cardioprotective effects. Trials to test this hypothesis are in progress. IS - 5 Suppl JF - Journal of the American College of Cardiology SN - 1558-3597 TI - Insulin as an anti-inflammatory and antiatherogenic modulator. VL - 53 KW - crp KW - cytokines KW - inflammation KW - inflammatory KW - insulin KW - review AU - Dandona, Paresh AU - Chaudhuri, Ajay AU - Ghanim, Husam AU - Mohanty, Priya PY - 2009/02/03/ UR - http://dx.doi.org/10.1016/j.jacc.2008.10.038 ER -