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The aged niche disrupts muscle stem cell quiescence

by: Joe V. Chakkalakal, Kieran M. Jones, M. Albert Basson, Andrew S. Brack
Nature, Vol. 490, No. 7420. (18 October 2012), pp. 355-360, doi:10.1038/nature11438  Key: citeulike:11340131

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Abstract

The expression of fibroblast growth factor in aged muscle fibre, the muscle stem cell niche, is shown to cause satellite cells to lose the capacity for self-renewal, and is thus an age-dependent change that directly influences stem cell quiescence and function.


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