GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Export

@article{citeulike:3072330, abstract = {Fluctuating neurosteroid levels over the ovarian cycle modulate neuronal excitability through effects on GABA(A) receptors (GABA(A)Rs). The large increase in progesterone-derived neurosteroids during pregnancy and their precipitous decline at parturition may have considerable effects on GABA(A)Rs during pregnancy and postpartum. Here we show a significant decrease in tonic and phasic inhibitions in pregnant mice, mediated by a downregulation of GABA(A)R delta and gamma2 subunits, respectively, which rebounds immediately postpartum. Mice which do not exhibit GABA(A)R delta subunit regulation throughout pregnancy (Gabrd(+/-) and Gabrd(-/-)) exhibit depression-like and abnormal maternal behaviors, resulting in reduced pup survival. These abnormal postpartum behaviors were ameliorated in Gabrd(+/-) mice by a GABA(A)R delta-subunit-selective agonist, THIP. We suggest that Gabrd(+/-) and Gabrd(-/-) mice constitute a mouse model of postpartum depression that may be useful for evaluating potential therapeutic interventions.}, address = {Department of Neurology, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.}, author = {Maguire, J. and Mody, I.}, citeulike-article-id = {3072330}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2008.06.019}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18667149}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18667149}, day = {31}, doi = {10.1016/j.neuron.2008.06.019}, issn = {1097-4199}, journal = {Neuron}, keywords = {081018, jc, junuk}, month = {July}, number = {2}, pages = {207--213}, posted-at = {2008-10-15 15:03:44}, priority = {2}, title = {GABA(A)R plasticity during pregnancy: relevance to postpartum depression.}, url = {http://dx.doi.org/10.1016/j.neuron.2008.06.019}, volume = {59}, year = {2008} }

TY - JOUR ID - citeulike:3072330 L3 - citeulike-article-id:3072330 N2 - Fluctuating neurosteroid levels over the ovarian cycle modulate neuronal excitability through effects on GABA(A) receptors (GABA(A)Rs). The large increase in progesterone-derived neurosteroids during pregnancy and their precipitous decline at parturition may have considerable effects on GABA(A)Rs during pregnancy and postpartum. Here we show a significant decrease in tonic and phasic inhibitions in pregnant mice, mediated by a downregulation of GABA(A)R delta and gamma2 subunits, respectively, which rebounds immediately postpartum. Mice which do not exhibit GABA(A)R delta subunit regulation throughout pregnancy (Gabrd(+/-) and Gabrd(-/-)) exhibit depression-like and abnormal maternal behaviors, resulting in reduced pup survival. These abnormal postpartum behaviors were ameliorated in Gabrd(+/-) mice by a GABA(A)R delta-subunit-selective agonist, THIP. We suggest that Gabrd(+/-) and Gabrd(-/-) mice constitute a mouse model of postpartum depression that may be useful for evaluating potential therapeutic interventions. IS - 2 JF - Neuron SN - 1097-4199 AD - Department of Neurology, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. EP - 213 TI - GABA(A)R plasticity during pregnancy: relevance to postpartum depression. VL - 59 SP - 207 KW - 081018 KW - jc KW - junuk AU - Maguire, J AU - Mody, I PY - 2008/07/31/ UR - http://dx.doi.org/10.1016/j.neuron.2008.06.019 ER -