Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Export

@article{citeulike:3442478, abstract = {Repeated exposure to cocaine causes sensitized behavioral responses and increased dendritic spines on medium spiny neurons of the nucleus accumbens (NAc). We find that cocaine regulates myocyte enhancer factor 2 (MEF2) transcription factors to control these two processes in vivo. Cocaine suppresses striatal MEF2 activity in part through a mechanism involving cAMP, the regulator of calmodulin signaling (RCS), and calcineurin. We show that reducing MEF2 activity in the NAc in vivo is required for the cocaine-induced increases in dendritic spine density. Surprisingly, we find that increasing MEF2 activity in the NAc, which blocks the cocaine-induced increase in dendritic spine density, enhances sensitized behavioral responses to cocaine. Together, our findings implicate MEF2 as a key regulator of structural synapse plasticity and sensitized responses to cocaine and suggest that reducing MEF2 activity (and increasing spine density) in NAc may be a compensatory mechanism to limit long-lasting maladaptive behavioral responses to cocaine.}, author = {Pulipparacharuvil, S. and Renthal, W. and Hale, C. F. and Taniguchi, M. and Xiao, G. and Kumar, A. and Russo, S. J. and Sikder, D. and Dewey, C. M. and Davis, M. M. and Greengard, P. and Nairn, A. C. and Nestler, E. J. and Cowan, C. W.}, citeulike-article-id = {3442478}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2008.06.020}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18760698}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18760698}, day = {28}, doi = {10.1016/j.neuron.2008.06.020}, issn = {1097-4199}, journal = {Neuron}, keywords = {081025, jc, jihye}, month = {August}, number = {4}, pages = {621--633}, posted-at = {2008-10-23 11:24:37}, priority = {2}, title = {Cocaine regulates MEF2 to control synaptic and behavioral plasticity.}, url = {http://dx.doi.org/10.1016/j.neuron.2008.06.020}, volume = {59}, year = {2008} }

TY - JOUR ID - citeulike:3442478 L3 - citeulike-article-id:3442478 N2 - Repeated exposure to cocaine causes sensitized behavioral responses and increased dendritic spines on medium spiny neurons of the nucleus accumbens (NAc). We find that cocaine regulates myocyte enhancer factor 2 (MEF2) transcription factors to control these two processes in vivo. Cocaine suppresses striatal MEF2 activity in part through a mechanism involving cAMP, the regulator of calmodulin signaling (RCS), and calcineurin. We show that reducing MEF2 activity in the NAc in vivo is required for the cocaine-induced increases in dendritic spine density. Surprisingly, we find that increasing MEF2 activity in the NAc, which blocks the cocaine-induced increase in dendritic spine density, enhances sensitized behavioral responses to cocaine. Together, our findings implicate MEF2 as a key regulator of structural synapse plasticity and sensitized responses to cocaine and suggest that reducing MEF2 activity (and increasing spine density) in NAc may be a compensatory mechanism to limit long-lasting maladaptive behavioral responses to cocaine. IS - 4 JF - Neuron SN - 1097-4199 EP - 633 TI - Cocaine regulates MEF2 to control synaptic and behavioral plasticity. VL - 59 SP - 621 KW - 081025 KW - jc KW - jihye AU - Pulipparacharuvil, S AU - Renthal, W AU - Hale, CF AU - Taniguchi, M AU - Xiao, G AU - Kumar, A AU - Russo, SJ AU - Sikder, D AU - Dewey, CM AU - Davis, MM AU - Greengard, P AU - Nairn, AC AU - Nestler, EJ AU - Cowan, CW PY - 2008/08/28/ UR - http://dx.doi.org/10.1016/j.neuron.2008.06.020 ER -